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ATF3 — STAT1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Kim et al., Cell Signal 2010
(Diabetes Mellitus, Experimental...) :
The
induction of
STAT1 gene by
activating transcription factor 3 contributes to pancreatic beta-cell apoptosis and its dysfunction in streptozotocin treated mice ... Furthermore,
STAT1 did not affect ATF3 expression, but STAT1 depletion or its inactivation
inhibited STZ induced
ATF3 nuclear translocation and beta-cell apoptosis ... Interestingly,
ATF3 also
increased STAT1 transcription by directly binding to a putative binding region ( -116 to -96 bp ) in the STAT1 promoter
Lu et al., J Dermatol 2013
:
Importantly, JUN may
regulate activating transcription factor 3 expression to involve cell proliferation process ;
STAT1 and STAT3 can inhibit tissue inhibitor of metalloproteinases-3 expression to modulate the cell adhesion molecule pathway ; NF-?B and E2F1 can downregulate cyclin D1, but upregulate proliferating cell nuclear antigen expression to promote the cell cycle pathway