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HMGB1 — MMP13

Text-mined interactions from Literome

Loeser et al., Arthritis Rheum 2005 (Osteoarthritis) : The ability of S100B and HMGB-1 to stimulate matrix metalloproteinase 13 (MMP-13) production was also assessed ... Stimulation of chondrocytes with S100B or HMGB-1 increased phosphorylation of the ERK MAP kinase and the p65 subunit of NF-kappaB and increased the production of MMP-13
García-Arnandis et al., Arthritis Res Ther 2010 (MAP Kinase Signaling System...) : In OA synoviocytes, HMGB1 alone at concentrations of 15 or 25 ng/ml did not affect the production of IL-6, IL-8, CCL2, CCL20, MMP-1 or MMP-3, but in the presence of IL-1ß, a significant potentiation of protein and mRNA expression, as well as MMP activity was observed ... In OA synoviocytes, HMGB1 alone at concentrations of 15 or 25 ng/ml did not affect the production of IL-6, IL-8, CCL2, CCL20, MMP-1 or MMP-3, but in the presence of IL-1ß, a significant potentiation of protein and mRNA expression, as well as MMP activity was observed
Wähämaa et al., Arthritis Res Ther 2011 (Arthritis, Rheumatoid...) : HMGB1 in complex with IL-1ß increased MMP production from both RASF and OASF