Gene interactions and pathways from curated databases and text-mining

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IGF1 — MARCKS

Text-mined interactions from Literome

Shiraishi et al., J Cell Physiol 2006 (Neuroblastoma) : The decrease in P-MARCKS induced by IGF-I was blocked by pretreatment of cells with phosphoinositide 3-kinase (PI3K) inhibitors, LY294002 and wortmannin
Yamaguchi et al., J Cell Physiol 2009 (Brain Neoplasms...) : On the other hand, the phosphoinositide 3-kinase inhibitor, LY294002, abolished IGF-I induced dephosphorylation, translocation of MARCKS to lipid rafts, and lamellipodia formation ... Immunocytochemical and immunoprecipitation analysis indicated that IGF-I stimulation induced the translocation of MARCKS to lipid rafts in the edge of lamellipodia and formation of the complex with PIP2