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EGF — TSG101

Text-mined interactions from Literome

Bache et al., Mol Biol Cell 2006 : Surprisingly, however, whereas depletion of Tsg101 caused sustained EGF activation of the mitogen activated protein kinase pathway, depletion of hVps24 had no such effect
Razi et al., Mol Biol Cell 2006 : Depletion of Tsg101 potently inhibits EGF degradation and MVB formation and causes the vacuolar domains of the early endosome to tubulate ... Together, these results indicate that Tsg101 is required for the formation of stable vacuolar domains within the early endosome that develop into MVBs and Hrs is required for the accumulation of internal vesicles within MVBs and that both these processes are up-regulated by EGF stimulation