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TAT — TGFB1

Text-mined interactions from Literome

Enam et al., Arch Pathol Lab Med 2004 (HIV Infections...) : These observations support our model, suggesting that the induction of transforming growth factor beta1 by human immunodeficiency virus 1 Tat can stimulate its downstream factors, including Smads 3 and 4, which in turn augment transcription of the JCV promoter in glial cells
Lotz et al., J Cell Biol 1994 : Further characterization of the interactions between Tat and TGF beta showed that Tat increased synthesis and TGF beta activity and TGF beta 1 mRNA levels
Cupp et al., Oncogene 1993 : Implications of the Tat mediated induction of TGF-beta 1 expression and cytokine involvement in the regulation of immune response and central nervous system ( CNS ) pathology are discussed
Rasty et al., Proc Natl Acad Sci U S A 1996 : In this report, a replication-defective herpes simplex virus ( HSV ) -1 tat gene transfer vector, dSTat, was used to transiently express HIV-1 Tat in glial cells in culture and following intracerebral inoculation in mouse brain in order to directly determine whether Tat can increase TGF-beta1 mRNA expression ... Tat mediated stimulation of TGF-beta1 expression suggests a novel pathway by which HIV-1 may alter the expression of cytokines in the central nervous system, potentially contributing to the development of AIDS associated neurological disease
Sawaya et al., J Neuroimmunol 1998 : Regulation of TNFalpha and TGFbeta-1 gene transcription by HIV-1 Tat in CNS cells ... Activation of the TGFbeta-1 and TNFalpha promoters by wild-type Tat was severely affected by the mutant peptides spanning residues 2 to 36 and 1 to 48 suggesting that both truncated Tat peptides may function as dominant negative mutants over TNFalpha and TGFbeta-1 gene transcription
Yamamoto et al., Kidney Int 1999 (AIDS-Associated Nephropathy) : Tat stimulated the expression and production of TGF-beta 1 and matrix proteins by human mesangial cells