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IL2 — TP53

Text-mined interactions from Literome

Chaudhry et al., J Immunol 2002 : In this study, we demonstrate that p53 directly inhibits expression of the T cell growth factor ( IL-2 ) in activated T cells ... Paradoxically, IL-2 repression by p53 is not reversed by mdm2
Torigoe et al., Leukemia 1992 : This finding that p53/56-LYN can be regulated by both IL-2 in B-lineage cells and IL-3 in myeloid committed cells demonstrates that the same SRC-family PTK can participate in signal transduction events mediated via two independent receptor systems
Mercer et al., Exp Cell Res 1985 : Moreover, the induction of p53 is dependent on the presence of the T-cell mitogen, Interleukin-2
Kobayashi et al., Proc Natl Acad Sci U S A 1993 : We observed that in this cell line, IL-2 induces activation of at least two src-PTKs, p59fyn ( fyn ) and p53/56lyn ( lyn )
Pesch et al., J Interferon Cytokine Res 1996 (Leukemia-Lymphoma, Adult T-Cell...) : Repression of interleukin-2 and interleukin-4 promoters by tumor suppressor protein p53 ... Murine wt p53 derived from pSG5p53cD strongly repressed the IL-2 and IL-4 promoters in both cell lines induced by the phorbol ester TPA and the Ca2+ ionophore ionomycin but not, however, in uninduced cells