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ING2 — TP53

Pathways - manually collected, often from reviews:

• WikiPathways Senescence and Autophagy in Cancer: TP53 → ING2 (unknown)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: ING2 — TP53 (physical association, affinity chromatography technology) Pedeux et al., Mol Cell Biol 2005*
• IRef Hprd Interaction: Complex of ING2-EP300-TP53-EP300-ING2-TP53-EP300-ING2-TP53 (in vivo) Wang et al., FEBS Lett 2006*
• IRef Intact Interaction: ING2 — TP53 (physical association, anti bait coimmunoprecipitation) Wang et al., FEBS Lett 2006*

Text-mined interactions from Literome

Zhang et al., Cancer Lett 2008 (Carcinoma, Hepatocellular...) : Researches have shown that ING2 can activate p53 and p53 mediated apoptotic pathway involved in the hepatocarcinogenesis
Ythier et al., Lung Cancer 2010 (Carcinoma, Non-Small-Cell Lung...) : Mechanistically, although p53 can regulate ING2 transcription and ING2 enhances p53 activity, no correlation between ING2 and p53 IHC status was observed