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RAF1 — TP53
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
TP53
→
RAF1
(directlyIncreases, TP53 Activity)
Evidence: 157,167 The antiapoptotic effects of C-Raf are also mediated through the ankyrin-repeat protein Tvl-1 and apoptosis signal-regulated kinase-1.166,168,169 In addition, C-Raf phosphorylates Rb, p53, Cdc25, and other cell cycle regulatory proteins in metaphase.
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Ritchie et al., Oncogene 1999
:
Furthermore, the expression of constitutively active
Raf1 in M07e cells
induced conformational change in
p53 independent of Tpo stimulation
Lee et al., Proc Natl Acad Sci U S A 2000
:
Finally, activation of MAPK by
p53 was
inhibited by expression of dominant negative Ras ( N17Ras ) and
Raf1 mutants, indicating that MAPK activation by p53 is mediated at a level upstream of Ras
Harikumar et al., J Exp Ther Oncol 2008
(Disease Progression...) :
The treatment with berberine, curcumin or picroliv were found to ( a ) elevate the life span of leukemia harboring animals by more than 60 days ; ( b ) decreased the anemic condition which was highly prevalent in FMuLv alone treated group ; ( c ) histopathological evaluations showed that the compounds tested here inhibited the massive leukemic cell infiltrations to sinusoidal spaces in spleen ; ( d ) decrease the expression of Bcl-2,
Raf-1 , Erk-1 IFNgamma receptor and erythropoietin ; ( e )
induce the expression of
p53
Zhu et al., Cancer Sci 2013
(Carcinoma, Renal Cell...) :
Mechanistic investigations indicated that therapy induced senescence ( TIS ) following sunitinib treatment mainly attributed to
p53/Dec1 signaling activation
mediated by
Raf-1/NF-?B inhibition in vitro
Blagosklonny et al., Cancer Res 1995
:
These data suggest that induction of p21WAF1 by taxol requires
c-raf-1 activity, but that it is not strictly
dependent on wild-type
p53