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MAPK8 — SCNN1A
Text-mined interactions from Literome
Frank et al., J Biol Chem 2003
:
The inhibitory effect of TGF-beta1 on sodium uptake and
alphaENaC expression in ATII cells was
mediated by activation of the
MAPK , ERK1/2
Roux et al., J Biol Chem 2005
(Edema) :
The inhibitory effect of IL-1beta on
alpha ENaC expression was
mediated by the activation of p38
MAPK in both rat and human ATII cells and was independent of the activation of alpha v beta6 integrin and transforming growth factor-beta ... This reduction in ion and water transport across the lung epithelium is in large part due to a decrease in alpha ENaC expression through p38
MAPK dependent inhibition of
alpha ENaC promoter activity and to an alteration in ENaC trafficking to the apical membrane of ATII cells
Niisato et al., Biochem Biophys Res Commun 2007
:
Moreover, we found that inhibition of p38
MAPK by SB202190
diminished the mRNA expression of beta- and gamma-ENaC but not
alpha-ENaC