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DCN — IGF2

Text-mined interactions from Literome

Chakraborty et al., Can J Physiol Pharmacol 2002 : Transforming growth factor beta ( TGF-beta ), decorin ( a proteoglycan in the ECM ), and melanoma cell adhesion molecule ( Mel-CAM ) inhibit, and insulin-like growth factor II (IGF-II) , IGF binding protein 1 (IGFBP-1), and endothelin 1 (ET-1) stimulate EVT cell migration/invasion
Iozzo et al., J Biol Chem 2011 (MAP Kinase Signaling System...) : However, there are no available data on the role of decorin in modulating IGF-IR activity in transformed cells or in tumor models ... Decorin bound with high affinity IGF-IR and IGF-I at distinct sites and negatively regulated IGF-IR activity in urothelial cancer cells ... Notably, decorin did not cause down-regulation of the IGF-IR in bladder, breast, and squamous carcinoma cells ... This indicates that decorin action on the IGF-IR differs from its known activity on other receptor tyrosine kinases such as the EGF receptor and Met ... Thus, decorin loss may contribute to increased IGF-IR activity in the progression of bladder cancer and perhaps other forms of cancer where IGF-IR plays a role