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MCL1 — PTGS2

Text-mined interactions from Literome

Choi et al., Exp Mol Med 2005 (Urinary Bladder Neoplasms) : Furthermore, COX-2 enhanced Mcl-1 expression in the anoikis process, implying that Mcl-1 also may be involved in mediating the survival function of COX-2
Kern et al., Cancer Res 2006 (Carcinoma, Hepatocellular...) : COX-2 inhibition led to a rapid down-regulation of myeloid cell leukemia-1 (Mcl-1) , an antiapoptotic member of the Bcl-2 family, followed by translocation of Bax to mitochondria and cytochrome c release from mitochondria ... Consequently, overexpression of Mcl-1 led to inhibition of COX-2 inhibitor mediated apoptosis
Liu et al., Ann Hematol 2007 (Leukemia) : Taken together, our results demonstrate for the first time that downregulation of cyclooxygenase-2 expression, disruption of mitochondrial membrane potential, activation of caspase-3, downregulation of Bcl-2, Bcl-Xl, and Mcl-1 , and upregulation of Bax are involved in PPAR-gamma agonists induced apoptosis in these two human monocyte leukemia cells
Kern et al., Verh Dtsch Ges Pathol 2007 (Carcinoma, Hepatocellular...) : COX-2 inhibition led to an increased surface expression of death receptors and a marked down-regulation of Mcl-1 , followed by translocation of Bax to mitochondria and a consecutive release of cytochrome c