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IDO1 — IL2
Text-mined interactions from Literome
Gordon et al., J Immunol 2005
(Asthma...) :
Splenic CD8alpha+ dendritic cells reportedly tolerize T cell responses by
inducing Fas ligand mediated apoptosis, suppressing
IL-2 expression, or catabolizing T cell tryptophan reserves through expression of
IDO
Li et al., Cancer Biol Ther 2009
:
We found that
IDO produced by IDO stably expressing CHO cells significantly
inhibited interleukin (IL)-2 expression and proliferative response in T cells and increased apoptosis of T cells
Carlin et al., J Leukoc Biol 1989
:
The
induction of
IDO activity by
IL-2 required both monocytes and lymphocytes ... Interaction was required between these populations for
induction of
IDO by
IL-2 , due to production of IFN-gamma by T lymphocytes, with subsequent IFN-gamma mediated induction of IDO in monocytes