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FOXO1 — PI3

Text-mined interactions from Literome

Nakae et al., J Biol Chem 1999 : The effect of insulin was inhibited by wortmannin treatment, suggesting that PI 3-kinase activity is required for FKHR phosphorylation
Perrot et al., J Biol Chem 2003 : Insulin inhibition of Foxo1- ( 208-652 ) -stimulated transactivation is mediated by PI 3-kinase but in contrast to full-length Foxo1, does not require either of the two PKB/Akt phosphorylation sites ( Ser253 and Ser316 ) present in the protein fragment
Weinkove et al., BMC biology 2006 : Long-term starvation and ageing induce AGE-1/PI 3-kinase dependent translocation of DAF-16/FOXO to the cytoplasm
Fothergill et al., Virology 2006 (MAP Kinase Signaling System) : VLP induced PI3-kinase activity resulted in efficient downstream signaling to Akt and consequent phosphorylation of FKHR and GSK3beta
Terragni et al., BMC cell biology 2008 : Computational analyses followed by chromatin immunoprecipitations demonstrated FOXO binding to both previously known and novel sites in promoter regions of approximately one-third of the up-regulated genes, consistent with activation of FOXO1 and FOXO3a in response to inhibition of PI 3-kinase
Ganopolsky et al., Journal of thrombosis and haemostasis : JTH 2008 : This effect was suppressed by the PI3K inhibitor wortmannin, demonstrating that FOXO1a phosphorylation is PI3-kinase dependent
Chen et al., J Biol Chem 2008 (MAP Kinase Signaling System) : In the present study we hypothesized that DHEA may stimulate PI 3-kinase dependent phosphorylation of FoxO1 in endothelial cells to help regulate endothelial function
Alam et al., Endocrinology 2009 : These results indicate that FSH stimulated HIF-1 activation leading to up-regulation of targets such as vascular endothelial growth factor requires not only PI3-kinase/AKT mediated activation of mammalian target of rapamycin as well as phosphorylation of FOXO1 and possibly MDM2 but also a protein ( kinase ) activity that is inhibited by the classic ERK kinase inhibitor PD98059 but not ERK1/2 or 5
Meur et al., J Biol Chem 2011 : FoxO1 activity is tightly controlled by phosphatidylinositol 3-kinase (PI3K) signaling, resulting in its phosphorylation and nuclear exclusion
Terragni et al., J Biol Chem 2011 : Inhibition of PI 3-kinase led to a loss of Max/Mnt binding and transcriptional induction by MITF and USF1, as well as FoxO
Kajimura et al., Cell Metab 2013 : Adiponectin fulfills these functions, independently of its known receptors and signaling pathways, by decreasing FoxO1 activity in a PI3-kinase dependent manner