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EGF — IGFBP1
Text-mined interactions from Literome
Grimes et al., Endocrinology 1992
:
However, in the
presence of
epidermal growth factor ( which was without independent effect on the 30-kDa IGFBP ), insulin also induced this 30-kDa
IGFBP
Barreca et al., Mol Cell Endocrinol 1992
:
The
stimulation of IGF-I and
IGFBP secretion by
EGF appears to be dose dependent with a significant increment already evident at 5 nM
Angervo et al., J Endocrinol 1992
:
These results suggest that
EGF regulates
IGFBP-1 secretion in human granulosa-luteal cells
Nuttinck et al., Domest Anim Endocrinol 2004
:
Under defined culture conditions,
IGFBP-2 and FSHR mRNA expression remained at a high level in TCM199 alone and were significantly
reduced ( P < 0.05 ) in the presence of 10 ng/ml
EGF after a 24 h period of in vitro maturation
Cavaillé et al., Biochem Biophys Res Commun 2006
:
IGFBP-1 inhibits
EGF mitogenic activity in cultured endometrial stromal cells
Mondschein et al., Endocrinology 1990
:
In contrast,
IGFBP-3 levels were
enhanced by
epidermal growth factor
Corps et al., Endocrinology 1991
:
Production of this
IGFBP by Swiss 3T3 cells was
stimulated by 50-150 % by the mitogens bombesin, vasopressin, platelet derived growth factor,
epidermal growth factor , and 12-O-tetradecanoylphorbol 13-acetate and also by IGF-I
Murray et al., Endocrinology 1993
:
The
IGFBP-1 response to
EGF was most dramatic in the first few days of life ... Although EGF lowered circulating insulin levels,
EGF stimulated
IGFBP-1 secretion in the presence of exogenously administered insulin
Oguchi et al., Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi 1997
:
The
effects of IGF-I and
EGF on
IGFBP secretion diminished with increasing cell differentiation