Kee et al., J Mol Cell Cardiol 2009
(Cardiomegaly) :
These results suggest that KLF4 , a novel anti-hypertrophic transcriptional regulator, mediates the HDAC inhibitor induced prevention of cardiac hypertrophy
Huang et al., Mol Pharmacol 2011
:
This finding, together with the HDAC inhibitor induced up-regulation of KLF4 and E-cadherin, suggests that HDAC inhibitors could activate the expression of these genes through changes in histone methylation status