◀ Back to VEGFA

DLL4 — VEGFA

Text-mined interactions from Literome

Liu et al., Mol Cell Biol 2003 : Regulation of Notch1 and Dll4 by vascular endothelial growth factor in arterial endothelial cells : implications for modulating arteriogenesis and angiogenesis
Mirkin et al., Menopause 2004 : Conversely, Delta4-tibolone , which is reported to have progestational-like activity, did not stimulate VEGF 121 and VEGF 165 but increased TSP-1 mRNA synthesis in cultured Ishikawa cells
Noguera-Troise et al., Nature 2006 (Neoplasms...) : We report that VEGF dynamically regulates tumour endothelial expression of Delta-like ligand 4 (Dll4) , which was previously shown to be absolutely required for normal embryonic vascular development ... Thus, VEGF induced Dll4 acts as a negative regulator of tumour angiogenesis ; its blockade results in a striking uncoupling of tumour growth from vessel density, presenting a novel therapeutic approach even for tumours resistant to anti-VEGF therapies
Lobov et al., Proc Natl Acad Sci U S A 2007 (Retinal Diseases) : Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sprouting ... We report that Dll4 expression is dynamically regulated by VEGF in the retinal vasculature, where it is most prominently expressed at the leading front of actively growing vessels ... Our data demonstrate that Dll4 is induced by VEGF as a negative feedback regulator and acts to prevent overexuberant angiogenic sprouting, promoting the timely formation of a well differentiated vascular network
Harrington et al., Microvasc Res 2008 : PlGF enhanced tubulogenesis of HUVEC suggesting that downregulation of PlGF and upregulation of VEGFR1 including sVEGFR1 are important mechanisms by which Dll4 attenuates PlGF and VEGF signalling
Noguera-Troise et al., Novartis Found Symp 2007 : We report that VEGF dynamically regulates tumour endothelial expression of Delta-like ligand 4 (Dll4) , which was previously shown to be absolutely required for normal embryonic vascular development ... Thus, VEGF induced Dll4 acts as a negative regulator of tumour angiogenesis ; its blockade results in a striking uncoupling of tumour growth from vessel density, presenting a novel therapeutic approach even for tumours resistant to anti-VEGF therapies
Hayashi et al., PloS one 2008 : Moreover, activation of the Dll4 and Hey2 promoters is induced by VEGF in conjunction with either Foxc1 or Foxc2 more than by either component alone
Martinez et al., Histopathology 2009 (Neoplasms...) : DLL4 is induced by vascular endothelial growth factor ( VEGF ) and acts downstream of VEGF as a ` brake ' on VEGF induced vessel growth, forming an autoregulatory negative feedback loop inactivating VEGF
Kume et al., Histol Histopathol 2010 : For arterial specification, vascular endothelial growth factor ( VEGF ) induces expression of Notch signaling genes, including Notch1 and its ligand, Delta-like 4 (Dll4) , and Foxc1 and Foxc2 transcription factors directly regulate Dll4 expression
Caolo et al., J Biol Chem 2010 : In the present study, we show that VEGF induced DLL4 expression depends on NOTCH activation ... VEGF induced DLL4 expression was prevented by the blockage of NOTCH signaling with ?-secretase or ADAM inhibitors in human cardiac microvascular ECs
Estrach et al., Circ Res 2011 : Furthermore, vascular endothelial growth factor stimulates laminin ?1 deposition, which leads to integrin signaling and Dll4 induction
Real et al., PloS one 2011 (Neoplasms...) : Here we show that SDF-1 and VEGF , which are produced by tumors, increase Dll4 expression on recruited BM-VPC