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ICAM1 — NFKBIA

Text-mined interactions from Literome

Weber et al., Blood 1999 : We found that overexpression of IkappaB-alpha in endothelial cells using a recombinant adenovirus prevented tumor necrosis factor-alpha (TNF-alpha) induced degradation of IkappaB-alpha and suppressed the upregulation of vascular cell adhesion molecule-1 ( VCAM-1 ), intercellular adhesion molecule-1 ( ICAM-1 ), and E-selectin mRNA and surface protein expression and the upregulation of transcripts for the chemokines monocyte chemoattractant protein 1 ( MCP-1 ) and growth related activity-alpha ( GRO-alpha ) by TNF-alpha
Amrani et al., J Immunol 1999 : Inhibition of cytokine mediated I kappa B alpha proteolysis using the protease inhibitors N-tosyl-L -phenylalanine chloromethyl ketone and N-acetyl-L -leucinyl-L -leucinyl-norleucinal also inhibited cytokine mediated early expression of ICAM-1
Park et al., Virology 2002 : The HDACI induced up-regulation of ICAM-1 , and consequent homotypic aggregation, were efficiently blocked by the addition of N-acetyl-L-cysteine and by ectopic expression of a super-repressor IkappaBalpha , while LPM-1 induction was unaffected, suggesting that these effects are mediated by NF-kappaB
Catley et al., Br J Pharmacol 2005 (Asthma) : Similarly, IKK beta ( KA ) and I kappa B alpha delta N overexpression also inhibited IL-1beta- and TNF alpha dependent increases in ICAM-1 , IL-8 and GM-CSF in addition to IL-1beta mediated increases in cyclooxygenase-2 expression, whereas IKK alpha ( KM ) overexpression had little effect on these outputs
Liao et al., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 2009 : The IKK-2 inhibitor, SC-514, inhibited IL-1beta induced IKappaBalpha protein activity, blocked p65 nuclear translocation, caused a significant reduction in IL-1beta induced DNA binding activity for p65 and ICAM-1 mRNA expression, and suppressed ICAM-1 expression on A549 cell surface ( all P < 0.01 )
Wu et al., American journal of physiology. Renal physiology 2009 (Nephritis) : However, the broad-spectrum caspase inhibitor Boc-d-fmk reduced NF-kB activation as assessed by gel shift assay, reduced phosphorylation of subunit IkappaBalpha , and significantly inhibited TNF induced expression of ICAM-1 and VCAM-1 as assessed by both real-time PCR and flow cytometry
Nam et al., J Ethnopharmacol 2009 : These results indicate that bigelovin inhibits inflammatory monocyte adhesion to endothelial cells and the expression of VCAM-1, ICAM-1 , and E-selectin by blocking IkappaBalpha degradation and NF-kappaB activation
Chen et al., J Immunol 1995 : Inhibition of I kappa B-alpha proteolysis resulted in the inhibition of the cytokine- and LPS induced transcriptional up-regulation and cell-surface expression of E-selectin, VCAM-1, and ICAM-1
Jobin et al., Gut 1998 : TNF-alpha induction of ICAM-1 expression is mediated by the transcription factor NF-kappa B and can be inhibited by blocking I kappa B alpha degradation
Lee et al., Proc Natl Acad Sci U S A 1999 (Lymphoma, B-Cell) : Overexpression of a dominantly active IkappaBalpha strongly inhibited CD40 induced NF-kappaB activation, ICAM-1 promoter activity, and cell-surface ICAM-1 up-regulation ... Overexpression of a dominantly active IkappaBalpha strongly inhibited CD40 induced NF-kappaB activation, ICAM-1 promoter activity, and cell-surface ICAM-1 up-regulation