Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Hashimoto et al., Clin Exp Allergy 2001 : The results showed that : NAC attenuated TNFalpha induced p38 MAP kinase activation and RANTES production ; SB 203580 as the specific inhibitor of p38 MAP kinase activity attenuated TNF-alpha induced RANTES production ; BSO facilitated TNF-alpha induced p38 MAP kinase activation and RANTES production ; SB 203580 attenuated BSO mediated facilitation of TNF-alpha induced RANTES production ; and the intracellular GSH increased in NAC treated cells, whereas the intracellular GSH was reduced in BSO treated cells
Chakraborty et al., Pharmacol Res 2008 : Also, Resveratrol was effective as an antioxidant in counteracting a rise in reactive oxygen species ( ROS ) and p38MAPK activation by H ( 2 ) O ( 2 ) was completely blocked by antioxidant N-acetyl cysteine (NAC)
Wang et al., Int J Oncol 2008 : Moreover, generation of reactive oxygen species ( ROS ) contributed to the cell death because N-acetyl-L-cystenine (NAC) , a ROS scavenger, suppressed the phosphorylation of p38 and the apoptosis
Lau et al., Br J Cancer 2010 (Adenocarcinoma...) : Brucein D-mediated activation of p38-MAPK was also inhibited by NAC
Chen et al., Cancer prevention research (Philadelphia, Pa.) 2012 (MAP Kinase Signaling System...) : This is evidenced by the findings that CPT induced ROS in a concentration- and time dependent manner ; CPT induction of ROS was inhibited by N-acetyl-L-cysteine (NAC) , a ROS scavenger ; and NAC attenuated CPT activation of p38/JNK , inhibition of Erk1/2, and induction of cell death