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Hashimoto et al., Clin Exp Allergy 2001
:
The results showed that :
NAC attenuated TNFalpha induced
p38 MAP kinase activation and RANTES production ; SB 203580 as the specific inhibitor of p38 MAP kinase activity attenuated TNF-alpha induced RANTES production ; BSO facilitated TNF-alpha induced p38 MAP kinase activation and RANTES production ; SB 203580 attenuated BSO mediated facilitation of TNF-alpha induced RANTES production ; and the intracellular GSH increased in NAC treated cells, whereas the intracellular GSH was reduced in BSO treated cells
Chakraborty et al., Pharmacol Res 2008
:
Also, Resveratrol was effective as an antioxidant in counteracting a rise in reactive oxygen species ( ROS ) and
p38MAPK activation by H ( 2 ) O ( 2 ) was completely
blocked by antioxidant
N-acetyl cysteine (NAC)
Wang et al., Int J Oncol 2008
:
Moreover, generation of reactive oxygen species ( ROS ) contributed to the cell death because
N-acetyl-L-cystenine (NAC) , a ROS scavenger,
suppressed the phosphorylation of
p38 and the apoptosis
Lau et al., Br J Cancer 2010
(Adenocarcinoma...) :
Brucein D-mediated activation of
p38-MAPK was also
inhibited by
NAC
Chen et al., Cancer prevention research (Philadelphia, Pa.) 2012
(MAP Kinase Signaling System...) :
This is evidenced by the findings that CPT induced ROS in a concentration- and time dependent manner ; CPT induction of ROS was inhibited by
N-acetyl-L-cysteine (NAC) , a ROS scavenger ; and NAC
attenuated CPT activation of
p38/JNK , inhibition of Erk1/2, and induction of cell death