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APCS — CD8A
Text-mined interactions from Literome
Donnini et al., Exp Gerontol 2002
:
APCs from old mice
induced similar lymphocyte proliferative responses but lower lymphocyte cytotoxicity and a reduced number of
CD8 ( + ) T cells producing IFNgamma in comparison with APCs from young animals
Gnjatic et al., J Immunol 2003
:
To address the antigenicity of long peptides, we analyzed two synthetic 30-mer peptides from NY-ESO-1, polypeptides 80-109 and 145-174, for their capacity to be processed by
APCs and to
stimulate CD8 ( + ) T cells
Sharma et al., Cancer Immunol Immunother 2008
(Mammary Neoplasms, Experimental) :
Analysis of the immune responses in the old indicated that CpG-ODN but not Poly-I:C induces : a pro-inflammatory Th1 type response ; accumulation and activation of CD4+,
CD8+ T and, NK cell responses ;
activation of
APCs ; and reduction in the number of Tregs
Guan et al., J Neuroimmunol 2007
(Disease Models, Animal...) :
These
APCs treated with M-CSF+autoantigen peptide significantly suppressed antigen-specific T cell proliferation,
induced regulatory CD4 ( + ) and
CD8 ( + ) T cells in vitro and in vivo, and significantly suppressed experimental autoimmune encephalomyelitis ( EAE )
Lee et al., J Immunol 2009
:
Furthermore, HBcAg-specific CD4 ( + ) and
CD8 ( + ) T cell priming with DNA encoding HBcAg does not
require B cell
APCs
Vanden Bush et al., J Immunol 2009
:
CD40- or TLR7 stimulated B cell
APCs induced similar
CD8 ( + ) T cell responses, but costimulation through the BCR and TLR7 produced a more effective Bvac as measured by T cell stimulation and the protection of mice from an infectious pathogen
Mauri et al., J Immunol 1995
:
Our data implicate that activated
T-APCs preferentially
induce a cytotoxic,
CD8+ and CD4+ T cell response