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Tashiro et al., Anticancer Drugs 2001
(Hepatoblastoma...) :
Additionally, the expression of GST-pi in HepG2 cells caused a decrease in GSH-DXR induced activation of caspase-3 , which was an apoptotic marker, whereas the suppression of GST-pi in HT29 cells showed an increase in caspase-3 activation
Asakura et al., Int J Cancer 2001
(Liver Neoplasms, Experimental) :
A conjugate of doxorubicin and glutathione via glutaraldehyde ( GSH-DXR ) inhibited glutathione S-transferase (GST) activity of rat hepatoma AH66 cells, and treatment of the cells with GSH-DXR induced caspase-3 activation and DNA fragmentation
Seitz et al., J Clin Immunol 2003
(MAP Kinase Signaling System) :
However, GST selectively inhibited the activity of the interleukin-1 converting enzyme (ICE)/caspase-1