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UCSC Genome Browser Gene Interaction Graph
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Gene interactions and pathways from curated databases and text-mining
◀ Back to PPP2CA
PPP2CA — PPP2R2A
Pathways - manually collected, often from reviews:
NCI Pathway Database TGF-beta receptor signaling :
PPP2CA (PPP2CA)
→
TGFB/TGFBR2/TGFBR1/PPP2R2A complex (TGFBR1-PPP2R2A-TGFBR2)
(modification, activates)
Petritsch et al., Genes Dev 2000
Evidence: physical interaction
NCI Pathway Database ErbB1 downstream signaling :
PPP2R1A/PPP2CA/PPP2R2A complex (PPP2R1A-PPP2CA-PPP2R2A)
→
KSR/14-3-3 complex (KSR1-YWHAH_YWHAZ_YWHAQ_SFN_YWHAE_YWHAG_YWHAB)
(modification, activates)
Ory et al., Curr Biol 2003
Evidence: assay
NCI Pathway Database ErbB1 downstream signaling :
PPP2R1A/PPP2CA/PPP2R2A complex (PPP2R1A-PPP2CA-PPP2R2A)
→
14-3-3 family (YWHAH/YWHAZ/YWHAQ/SFN/YWHAE/YWHAG/YWHAB)
(modification, activates)
Ory et al., Curr Biol 2003
Evidence: assay
NCI Pathway Database ErbB1 downstream signaling :
PPP2R1A/PPP2CA/PPP2R2A complex (PPP2R1A-PPP2CA-PPP2R2A)
→
KSR (KSR1)
(modification, activates)
Ory et al., Curr Biol 2003
Evidence: assay
NCI Pathway Database ErbB1 downstream signaling :
PPP2R1A/PPP2CA/PPP2R2A complex (PPP2R1A-PPP2CA-PPP2R2A)
→
PPP2R1A/PPP2CA complex (PPP2R1A-PPP2CA)
(modification, collaborate)
Ory et al., Curr Biol 2003
Evidence: assay
NCI Pathway Database ErbB1 downstream signaling :
PPP2R1A/PPP2CA/PPP2R2A complex (PPP2R1A-PPP2CA-PPP2R2A)
→
PPP2R2A (PPP2R2A)
(modification, collaborate)
Ory et al., Curr Biol 2003
Evidence: assay
NCI Pathway Database ErbB1 downstream signaling :
PPP2R1A/PPP2CA complex (PPP2R1A-PPP2CA)
→
PPP2R2A (PPP2R2A)
(modification, collaborate)
Ory et al., Curr Biol 2003
Evidence: assay
Reactome Reaction :
PPP2R2A
→
PPP2CA
(direct_complex)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
IRef Biogrid Interaction :
PPP2CA
—
PPP2R2A
(colocalization, biochemical)
Havugimana et al., Cell 2012
IRef Biogrid Interaction :
PPP2CA
—
PPP2R2A
(direct interaction, pull down)
Kamibayashi et al., J Biol Chem 1992 *
IRef Biogrid Interaction :
PPP2CA
—
PPP2R2A
(association, biochemical)
Kamibayashi et al., J Biol Chem 1992 *
IRef Biogrid Interaction :
PPP2CA
—
PPP2R2A
(physical association, affinity chromatography technology)
Goudreault et al., Mol Cell Proteomics 2009
IRef Biogrid Interaction :
PPP2CA
—
PPP2R2A
(physical association, affinity chromatography technology)
Glatter et al., Molecular systems biology 2009
IRef Dip Interaction :
Complex of 13 proteins
(physical association, pull down)
Takemoto et al., Nature structural & molecular biology 2009 *
IRef Hprd Interaction :
Complex of 73 proteins
(in vivo)
Al-Hakim et al., J Cell Sci 2005
IRef Hprd Interaction :
PPP2R2A
—
PPP2CA
(in vitro)
Kamibayashi et al., J Biol Chem 1992 *
IRef Intact Interaction :
Complex of PPP2R2A-EIF4A1-KIAA1524-PPP2R5D-PPP2R1A-PPP2CA-PPME1-PPP2R3A
(association, tandem affinity purification)
Puustinen et al., Cancer Res 2009
IRef Intact Interaction :
Complex of 13 proteins
(physical association, tandem affinity purification)
Hutchins et al., Science 2010
IRef Intact Interaction :
Complex of 34 proteins
(association, anti tag coimmunoprecipitation)
Goudreault et al., Mol Cell Proteomics 2009
IRef Intact Interaction :
Complex of 23 proteins
(association, anti tag coimmunoprecipitation)
Goudreault et al., Mol Cell Proteomics 2009
IRef Intact Interaction :
Complex of 29 proteins
(association, anti tag coimmunoprecipitation)
Glatter et al., Molecular systems biology 2009
IRef Intact Interaction :
Complex of 24 proteins
(association, anti tag coimmunoprecipitation)
Glatter et al., Molecular systems biology 2009
IRef Intact Interaction :
Complex of 19 proteins
(association, tandem affinity purification)
Goudreault et al., Mol Cell Proteomics 2009
IRef Intact Interaction :
Complex of SIK2-VCP-PPP2R1B-PPP2CA-PPP2R2A
(association, tandem affinity purification)
Al-Hakim et al., J Cell Sci 2005
IRef Intact Interaction :
Complex of 19 proteins
(association, anti tag coimmunoprecipitation)
Sablina et al., Cell 2007
IRef Intact Interaction :
Complex of PPME1-PPP2R2A-EIF4A1-PPP2CA-PPP2R1A
(association, tandem affinity purification)
Junttila et al., Proteomics 2005
IRef Intact Interaction :
Complex of 22 proteins
(association, anti tag coimmunoprecipitation)
Sablina et al., Cell 2007
IRef Ophid Interaction :
PPP2CA
—
PPP2R2A
(aggregation, confirmational text mining)
Kamibayashi et al., J Biol Chem 1992 *
IRef Ophid Interaction :
PPP2CA
—
PPP2R2A
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005