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GHR — IRF6

Text-mined interactions from Literome

Denson et al., J Clin Invest 2001 : TNF-alpha was integral to this response, as LPS did not affect hepatic Sp1/Sp3 binding or GHR expression in TNF receptor 1-deficient mice
Priego et al., J Endocrinol 2002 (Shock, Septic) : These data indicate that the adrenal axis may mediate the inhibitory effect of LPS on GHR and IGF-I synthesis in the liver
Granado et al., J Endocrinol 2006 (Body Weight...) : These results suggest that Kupffer cells are important mediators in the inhibitory effect of LPS on GHR , IGF-I and IGFBP-3 gene expression in the liver, leading to a decrease in serum concentrations of IGF-I and IGFBP-3
Dejkhamron et al., Mol Cell Endocrinol 2007 : The prevailing explanation for LPS induced effects on the GHR promoter is that this effect is indirect via generation of cytokines ... In HEK 293T cells, which are devoid of endogenous TLR4 or MD2, ectopic expression of TLR4 and MD2 resulted in LPS induced inhibition of the GHR promoter activity ... The essential role of the cofactor MD2 on the effect of LPS on the GHR promoter was established in experiments using ectopic expression of wild type and mutant MD2 ... The effect of LPS on the endogenous GHR promoter activity and protein expression was confirmed in F442A preadipocyte cells ... In HEK 293T cells, ectopic expression of mutant MyD88 or mutant TRIF abrogated the effect of LPS on the GHR promoter, suggesting that the effect of LPS on the GHR promoter was via both MyD88 dependent and -independent pathways ... LPS acts through both MyD88 dependent and -independent TLR4 signaling pathways to directly inhibit GHR gene expression