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FOSL1 — MMP1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Tower et al., Eur J Biochem 2003
:
In this study we demonstrate that the expression of Fos-like region antigen (
Fra-1 ), an AP-1 transcription factor component that also correlates strongly with neoplastic disease, is
necessary for
MMP-1 transcription in A2058 melanoma cells
Belguise et al., Oncogene 2005
(Breast Neoplasms...) :
Fra-1 regulated several genes, implicated in invasion, angiogenesis and cell proliferation independently of beta1-integrin activation, and directly
induced MMP-1 and MMP-9 promoter activity
Adiseshaiah et al., J Cell Physiol 2008
(Lung Neoplasms...) :
Furthermore,
Fra-1 induced EGFR phosphorylation in an
MMP dependent manner, and an EGFR-specific inhibitor was able to block Fra-1 enhanced cell motility and invasion