Sundaram et al., J Cell Biochem 2008
:
We show HSF-2 co-immune precipitated with DACH1 and that FGF-2 stimulation significantly increased ( 2.7-fold ) HSF-2 binding to DACH1 Watanabe et al., Proc Natl Acad Sci U S A 2011
(Brain Neoplasms...) :
Gene expression analysis and chromatin immunoprecipitation assay reveal that fibroblast growth factor 2 ( FGF2/bFGF ) is transcriptionally repressed by DACH1 , especially in cells cultured in serum-free medium ... Exogenous bFGF rescues spheroid forming activity and tumorigenicity of the U87-DACH1-high cells, suggesting that loss of DACH1 increases the number of tumor initiating cells through transcriptional activation of bFGF