◀ Back to IFNG

IFNG — SPP1

Text-mined interactions from Literome

O'Regan et al., J Leukoc Biol 2000 : Osteopontin augments CD3 mediated interferon-gamma and CD40 ligand expression by T cells, which results in IL-12 production from peripheral blood mononuclear cells ... Herein, we demonstrate that osteopontin stimulation augments the ability of anti-CD3 monoclonal antibody to induce CD40 ligand (CD40L) and IFN-gamma expression on human T cells, resulting in CD40L- and IFN-gamma dependent IL-12 production in vitro
Koguchi et al., Am J Respir Crit Care Med 2003 (Sarcoidosis, Pulmonary...) : In vitro experiments showed that OPN production by peripheral blood mononuclear cells infected with Mycobacterium bovis bacillus Calmette-Guérin preceded the synthesis of IL-12 and interferon-gamma and that the neutralizing anti-OPN monoclonal antibody significantly reduced the production of IL-12 and interferon-gamma
Morimoto et al., Int Immunol 2004 (Drug-Induced Liver Injury...) : Second, OPN deficiency resulted in the reduction of IL-12 and IFN-gamma production at early stages
Inomata et al., Cytokine 2005 (Disease Progression...) : Circulating IFN-gamma, IL-12, IL-18 and OPN paralleled the extent of lung lesions, and circulating IFN-gamma , IL-18 and OPN paralleled the magnitude of fever in patients with pulmonary tuberculosis
Mas et al., Mult Scler 2007 (Genetic Predisposition to Disease...) : OPN enhances the production of the pro-inflammatory cytokines, interleukin-12 and interferon-gamma , while reducing interleukin-10 levels
Agnholt et al., Scand J Immunol 2007 (Crohn Disease) : The in vitro effect of OPN stimulation on T-cell IFN-gamma , TNF-alpha, and IL-10 production was measured ... OPN increased CD69 and CD25 expression and enhanced T-cell IFN-gamma and TNF-alpha production in a dose dependent fashion with higher levels in CD than in healthy controls ( HC ), but induced a concomitant higher IL-10 production in HC than CD
Lu et al., Allergy 2009 (Nasal Polyps...) : On the contrary, OPN induced IFN-gamma , IL-4, IL-5, IL-13, IL-1beta, and TNF-alpha production in sinonasal mucosa
Seier et al., Am J Pathol 2010 (Chronic Disease...) : Furthermore, interferon-gamma from T effector cells augments OPN in allergic contact dermatitis by inducing OPN in keratinocytes, which in turn polarizes dendritic cells and attracts inflammatory cells
Murugaiyan et al., Proc Natl Acad Sci U S A 2010 (Encephalomyelitis, Autoimmune, Experimental) : Here, we show that IFN-gamma induces IL-27 while inhibiting OPN expression in DCs both in vitro and in vivo and that engagement of IFN-gammaR expressed by DCs leads to suppression of IL-17 production while inducing IL-10 from T cells
Singh et al., J Biol Chem 1995 : In vitro, interleukin-1 beta and interferon-gamma increased osteopontin mRNA levels in CMEC as well as NOS2 expression in both CMEC and cardiac myocytes