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AKT1 — TRIB3
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Koo et al., Nat Med 2004
(Diabetes Mellitus, Type 2...) :
Hepatic insulin sensitivity was enhanced in PGC-1-deficient mice, reflecting in part the reduced expression of the mammalian tribbles homolog
TRB-3 , a fasting-inducible
inhibitor of the serine-threonine kinase
Akt/PKB ( ref. 6 )
Prudente et al., J Clin Endocrinol Metab 2009
(Diabetes Mellitus, Type 2) :
TRIB3 inhibits insulin stimulated
Akt phosphorylation and subsequent insulin action
Liu et al., Am J Physiol Endocrinol Metab 2010
(Diabetes Mellitus, Type 2...) :
Tribbles homolog 3 (TRIB3) was found to
inhibit insulin stimulated
Akt phosphorylation and modulate gluconeogenesis in rodent liver
Salazar et al., Biochim Biophys Acta 2013
(Neoplasms, Experimental) :
Our data support the idea that THC induced
TRIB3 up-regulation
inhibits AKT phosphorylation by regulating the accessibility of AKT to its upstream activatory kinase ( the mammalian target of rapamycin complex 2 ; mTORC2 )