◀ Back to IL6

IL6 — PLA2G4A

Text-mined interactions from Literome

Wu et al., Hepatology 2002 (Bile Duct Neoplasms...) : HGF and IL-6 also induced a rapid phosphorylation of cPLA(2) ( within 1 minute ) but did not alter cPLA(2) and COX-2 protein expression ... The HGF- and IL-6 induced cPLA(2) phosphorylation was blocked by the inhibitors of p38 and p42/44 MAP kinases, protein kinase C, calmodulin kinase, and tyrosine kinase, showing that HGF- and IL-6 induced AA release and PG production are mediated by phosphorylation of cPLA(2)
Wang et al., Cell Biochem Funct 2004 : The mediating role of cPLA2 in IL-1 beta and IL-6 release in LPS induced HeLa cells
Karadag et al., Blood 2006 (MAP Kinase Signaling System...) : Furthermore, inhibitors of p38 MAPK and cPLA2 , but not NF-kappaB and JAK2, signaling pathways inhibited ADAM-9 induced IL-6 production by hOBs ( P < .01 )
Sooranna et al., Mol Hum Reprod 2006 : In primary cultures of uterine myocytes, cPLA(2) mRNA expression was increased by IL-1beta and IL-6 ; PGHS-2 mRNA expression was increased by IL-1beta, PGE ( 2 ) and stretch ; and PGES-1 mRNA expression was increased by IL-1beta only
Wang et al., Prostaglandins Other Lipid Mediat 2008 : p38 MAPK inhibitor SB203580 suppressed interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) release, as well as the activation of cPLA(2)
Lefebvre et al., FASEB J 2010 : As negative controls, interleukin-8- and formyl-methionyl-leucyl-phenylalanine elicited migration in vitro was not inhibited either by an LTB ( 4 ) receptor antagonist or by the cPLA(2)alpha inhibitor
Lee et al., Am J Pathol 2010 (Inflammation) : These results demonstrate that LTA induced MAPKs activation is mediated through the TLR2/MyD88/PI3K/Rac1/Akt pathway, which in turn initiates the activation of NF-kappaB, and ultimately induces cPLA(2)/COX-2 dependent PGE ( 2 ) and IL-6 generation
Chi et al., Arthritis Rheum 2011 (Arthritis, Rheumatoid) : Cytosolic phospholipase A2 induction and prostaglandin E2 release by interleukin-1ß via the myeloid differentiation factor 88-dependent pathway and cooperation of p300, Akt, and NF-?B activity in human rheumatoid arthritis synovial fibroblasts
Kawaguchi et al., J Bone Miner Res 1996 (Bone Resorption) : We conclude that ( 1 ) IL-1, TNF-alpha, and PTH, but not IL-6 nor IL-11, can increase the expression of PGHS-2, cPLA2 , and PGE2 production in cultured mouse calvariae ; ( 2 ) IL-4 inhibits PGE2 production in both control and stimulated calvarial cultures by inhibiting PGHS-2 and cPLA2 ; and ( 3 ) IL-4 has an inhibitory effect on bone resorption which is independent of PG production