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CDKN1A — PRKACG
Text-mined interactions from Literome
Rao et al., Exp Cell Res 1999
(Breast Neoplasms) :
In the present study we examined the
role of cAMP dependent
protein kinase (PKA) on
p21 and p27 induction in the breast cancer cell line, MDA-MB-157
Lee et al., Oncogene 2000
(Lung Neoplasms) :
Furthermore,
PKA activators forskolin and dibutyryl-cAMP activated p21WAFI promoter activity and
increased p21wAF1 protein level in lung cancer cells ... Taken together, these results demonstrate that Tam activates the p21WAF1 promoter via Sp1 binding sites and suggest that
PKA may be
involved in the induction of
p21wAF1 by Tam in ER-negative lung cancer cells
D'Souza et al., Am J Physiol Cell Physiol 2003
:
The increased levels of p53 and
p21 observed in eNOS transfected cells were
reduced in the presence of the
PKA inhibitor ... These data suggest that
p21 and p53 play a role in the inhibition of proliferation in eNOS transfected cells and that levels of these two proteins are
regulated by
PKA
Begum et al., J Biol Chem 2011
(MAP Kinase Signaling System) :
We conclude that PDE3A regulates VSMC growth via two complementary pathways, i.e. PKA catalyzed inhibitory phosphorylation of Raf-1 with resulting inhibition of MAPK signaling and
PKA/CREB mediated induction of
p21 , leading to G0/G1 cell cycle arrest, as well as by increased accumulation of p53, which induces MKP-1, p21, and WIP1, leading to inhibition of G1 to S cell cycle progression