◀ Back to CASP8
CASP8 — CAT
Text-mined interactions from Literome
Kashiwagi et al., Free Radic Biol Med 1999
:
Kinetic analysis revealed that
catalase activity decreased and
caspase-3-like activity
increased during normal tadpole tail atrophy ( apoptosis )
Jiang et al., J Neurochem 2001
:
Genetic up-regulation of
catalase not only significantly reduced cell death but also
suppressed caspase 3 activity and DNA fragmentation ... However, unlike inducibly increased
catalase expression and general
caspase inhibition both of which protect cells from cytotoxicity, caspase 3 inhibition alone did not improve cell survival suggesting that prevention of DNA fragmentation is insufficient to prevent H ( 2 ) O ( 2 ) -mediated cell death
Lavastre et al., Clin Immunol 2002
:
In addition, toxaphene was found to induce the degradation of the cytoskeletal proteins gelsolin, paxillin, and vimentin during apoptosis, and this was reversed by the addition of z-VAD-FMK (
caspase inhibitor ) or
catalase , demonstrating the importance of caspases and ROS in this process
Wang et al., Zhonghua Yan Ke Za Zhi 2003
:
[
Effect of N-acetyl-L-cysteine and
catalase on apoptosis of lens epithelial cell and the activity of
caspase-3 ]
Poh et al., Cancer Res 2005
(Prostatic Neoplasms) :
Indeed, overexpression of
catalase significantly
blocked the amplifying effect of LY pretreatment on caspase-2 and
caspase-3 activation and cell death triggered by vincristine
Yasui et al., Free radical research 2005
(Down Syndrome...) :
Catalase inhibited the neutrophil apoptosis and
caspase-3 activation
Kim et al., FEBS Lett 2006
(Melanoma) :
On further investigating the IAA/HRP mediated apoptotic pathway, we found that the IAA/HRP reaction leads to
caspase-3 activation and poly ( ADP-ribose ) polymerase ( PARP ) cleavage, which was also
blocked by
catalase
Yu et al., Cancer Lett 2008
(Leukemia) :
The apoptosis induction ability of ETME was associated with the production of hydrogen peroxide ( H ( 2 ) O ( 2 ) ), the decrease of mitochondrial membrane potential, and the activation of
caspase-3 that was
blocked by
catalase
Pramanik et al., PloS one 2011
(Pancreatic Neoplasms) :
Our results reveal that the release of cytochrome c and cleavage of both
caspase-9 and caspase-3 due to disruption of mitochondrial membrane potential were significantly
blocked by
catalase and EUK-134 in BxPC-3 cells