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Chien et al., J Biol Chem 2004
(Adenocarcinoma...) :
Cyr61 induced caspase-3 activation and depolarization of mitochondrial membrane
Lee et al., Food Chem Toxicol 2013
:
Silencing of Cyr61 by siRNA induced enhanced activity of caspase-3/7 , upregulation of the proapototic Bok, BimL and BimS, cleavage of apoptosis hallmarkers such as Bax, PARP and caspase-3, and downregulation of antiapoptotic Bcl2, Bcl-xL and Mcl-1 proteins