◀ Back to PAK1
LIMK2 — PAK1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Sumi et al., J Biol Chem 2001
:
Pak1 and ROCK, respectively,
activate LIMK1 and
LIMK2 downstream of Rac and Rho ; however, an effector protein kinase for LIMKs downstream of Cdc42 remains to be defined
Thirone et al., Am J Physiol Cell Physiol 2009
:
Hyperosmolarity provoked cofilin phosphorylation was mediated by the Rho/Rho kinase ( ROCK ) /LIM kinase ( LIMK ) but not the Rac/PAK/LIMK pathway, because 1 ) dominant negative ( DN ) Rho and DN-ROCK but not DN-Rac and DN-PAK inhibited cofilin phosphorylation ; 2 ) constitutively active ( CA ) Rho and CA-ROCK but not CA-Rac and
CA-PAK induced cofilin phosphorylation ; 3 ) hyperosmolarity induced LIMK-2 phosphorylation, and 4 ) inhibition of ROCK by Y-27632
suppressed the hypertonicity triggered
LIMK-2 and cofilin phosphorylation.We thenexamined whether cofilin and its phosphorylation play a role in the hypertonicity triggered F-actin changes ... Hyperosmolarity provoked cofilin phosphorylation was mediated by the Rho/Rho kinase ( ROCK )
/LIM kinase ( LIMK ) but not the Rac/PAK/LIMK pathway, because 1 ) dominant negative ( DN ) Rho and DN-ROCK but not DN-Rac and DN-PAK inhibited cofilin phosphorylation ; 2 ) constitutively active ( CA ) Rho and CA-ROCK but not CA-Rac and
CA-PAK induced cofilin phosphorylation ; 3 ) hyperosmolarity induced LIMK-2 phosphorylation, and 4 ) inhibition of ROCK by Y-27632 suppressed the hypertonicity triggered LIMK-2 and cofilin phosphorylation.We thenexamined whether cofilin and its phosphorylation play a role in the hypertonicity triggered F-actin changes
Ho et al., Pigment Cell Melanoma Res 2013
(Melanoma...) :
Molecular studies revealed that RHOJ alters actin cytoskeletal dynamics by inducing the phosphorylation of
LIMK , cofilin, and p41-ARC ( ARP2/3 complex subunit ) in a
PAK1 dependent manner in vitro and in tumor xenografts