Gene interactions and pathways from curated databases and text-mining

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IGF2 — SETD2

Text-mined interactions from Literome

Dimova et al., Thromb Haemost 2005 (MAP Kinase Signaling System...) : Furthermore, IGF-1 enhanced HIF-1alpha protein levels and HIF-1 DNA binding to each HRE, E4 and E5 as shown by EMSA
Pringle et al., Placenta 2007 : In conclusion, Hif-1alpha and Hif-2alpha are differentially regulated by oxygen and IGF-II in cultured trophoblast cells and asHif-1alpha may mediate the response to prolonged hypoxia in murine trophoblasts
Thomas et al., Prostate 2009 (Prostatic Neoplasms) : Furthermore, HIF-1alpha suppression attenuated the serum deprivation mediated increase in Akt and IGF-IR activation
Yu et al., Brain Res 2012 : Moreover, IGF-1 stimulated HIF-1a and GLUT3 protein expression through phosphatidylinositol 3-kinase (PI3K)/Akt/mTOR dependent pathways
Sartori-Cintra et al., Clinics (Sao Paulo) 2012 (Osteoarthritis) : In contrast, IGF-II did not affect the protein or gene expression levels of HIF-1a
Piecewicz et al., PloS one 2012 : We confirmed that IGF-IGFR1 signaling stabilizes HIF1a and leads to up-regulation of VEGF during vasculogenesis in embryoid bodies
Kurabayashi et al., PloS one 2013 : Because the effect of IGF-I on HIF-1a protein synthesis is mediated by IGF-IR , our results indicated that VHL inactivation accelerated hepatic glucose storage through the upregulation of IGF-IR and GLUT1 and that IGF-IR was a key regulator in VHL-deficient hepatocytes