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IGF2 — SETD2
Text-mined interactions from Literome
Dimova et al., Thromb Haemost 2005
(MAP Kinase Signaling System...) :
Furthermore,
IGF-1 enhanced HIF-1alpha protein levels and
HIF-1 DNA binding to each HRE, E4 and E5 as shown by EMSA
Pringle et al., Placenta 2007
:
In conclusion,
Hif-1alpha and Hif-2alpha are differentially
regulated by oxygen and
IGF-II in cultured trophoblast cells and asHif-1alpha may mediate the response to prolonged hypoxia in murine trophoblasts
Thomas et al., Prostate 2009
(Prostatic Neoplasms) :
Furthermore,
HIF-1alpha suppression
attenuated the serum deprivation mediated increase in Akt and
IGF-IR activation
Yu et al., Brain Res 2012
:
Moreover,
IGF-1 stimulated
HIF-1a and GLUT3 protein expression through phosphatidylinositol 3-kinase (PI3K)/Akt/mTOR dependent pathways
Sartori-Cintra et al., Clinics (Sao Paulo) 2012
(Osteoarthritis) :
In contrast,
IGF-II did not
affect the protein or gene expression levels of
HIF-1a
Piecewicz et al., PloS one 2012
:
We confirmed that
IGF-IGFR1 signaling
stabilizes HIF1a and leads to up-regulation of VEGF during vasculogenesis in embryoid bodies
Kurabayashi et al., PloS one 2013
:
Because the effect of IGF-I on
HIF-1a protein synthesis is
mediated by
IGF-IR , our results indicated that VHL inactivation accelerated hepatic glucose storage through the upregulation of IGF-IR and GLUT1 and that IGF-IR was a key regulator in VHL-deficient hepatocytes