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FGF2 — SETD2

Text-mined interactions from Literome

Semenza et al., Cancer Cell 2004 (Neoplasms...) : In this issue of Cancer Cell, now provide evidence that radiation induces HIF-1 mediated expression of VEGF and bFGF in tumor cells, which promotes endothelial cell survival
Shi et al., Zhonghua Yi Xue Za Zhi 2004 (Breast Neoplasms) : [ Activation of HIF-1 by bFGF in breast cancer : role of PI-3K and MEK1/ERK pathways ] ... Luciferase assay showed that SU5402 and PD98059 inhibited the bFGF induced transcription activity of HIF-1 by 94.8 % and 81.7 % respectively ... LY294002 not only completely inhibited the bFGF induced transcription activity of HIF-1 but also inhibited the basic transcription of HIF-1, and SB203580 did not significantly influence the transcription activity of HIF-1 ... bFGF activates HIF-1 via the PI-3K/Akt and MEK1/ERK pathways that co-operatively and differentially regulate this process with PI-3K/Akt pathway playing a more important role
Shi et al., J Pathol 2005 (Breast Neoplasms) : In vitro study of HIF-1 activation and VEGF release by bFGF in the T47D breast cancer cell line under normoxic conditions : involvement of PI-3K/Akt and MEK1/ERK pathways ... In the present study, the mechanisms underlying basic fibroblast growth factor (bFGF) induced activation of HIF-1 and the subsequent release of vascular endothelial growth factor ( VEGF ) in a human breast cancer cell line ( T47D ) under normoxic conditions were explored