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CHGA — EDN1

Text-mined interactions from Literome

Chen et al., J Am Soc Nephrol 2009 (Chronic Disease...) : Chromogranin A (CHGA) , a protein released from secretory granules of chromaffin cells and sympathetic nerves, triggers endothelin-1 release from endothelial cells ... Here, CHGA led to the release of endothelin-1 and Weibel-Palade body exocytosis in cultured human umbilical vein endothelial cells ... In addition, CHGA triggered secretion of endothelin-1 from glomerular endothelial cells and TGF-beta1 from mesangial cells cocultured with glomerular endothelial cells
Chen et al., Cell Mol Neurobiol 2010 (Genetic Predisposition to Disease...) : These findings, coupled with stimulation of endothelin-1 release from glomerular capillary endothelial cells by CHGA , suggest a plausible mechanism whereby genetic variation at the CHGA locus eventuates in alterations in human renal function