◀ Back to NFKB1
CASP2 — NFKB1
Text-mined interactions from Literome
Chakravortty et al., Infect Immun 2001
:
Similarly, a
caspase 3-specific inhibitor, Z-Asp-Glu-Val-Asp-fluoromethylketone,
inhibited NO production,
NF-kappaB activation, and JNK/SAPK phosphorylation in LPS stimulated RAW cells
Neuzil et al., Biochemistry 2001
(Inflammation) :
Our data infer a pathway by which
caspase activation in EC
inhibits NF kappa B-dependent inflammatory activation and monocyte recruitment, and provide evidence for a relationship between pro-apoptotic and anti-inflammatory pathways
Yang et al., Am J Physiol Gastrointest Liver Physiol 2001
(Fatty Liver) :
Fatty liver vulnerability to endotoxin induced damage despite
NF-kappaB induction and
inhibited caspase 3 activation
Kühn et al., Arthritis Rheum 2001
:
These results suggest that CD95 dependent cell death is enhanced by
NF-kappaB inhibition at and/or downstream of caspase 8 activation and that
caspase 9 activation is not
involved in CD95 mediated apoptosis in chondrocytes
Hu et al., Cancer Res 2001
(Leukemia, Myeloid...) :
Although Bay 11-7085 prevented phorbol 12-myristate 13-acetate induced NF-kappaB nuclear translocation, SN50, a specific inhibitor of nuclear translocation and function of
NF-kappaB , did not
induce any significant nuclear/DNA fragmentation,
caspase 3 activation, or cell death
Kim et al., J Neurosci 2001
(Spinal Cord Injuries...) :
NF-kappaB transactivates c-IAP2 to
inhibit caspase-3 activation
Bernal et al., Blood 2001
(Leukemia, Lymphocytic, Chronic, B-Cell) :
The response includes inhibition of
caspase activity,
activation of
NF-kappaB , and expression of mcl-1, bcl-2, and bfl-1 in the tumor cells
Cahir-McFarland et al., Recent Results Cancer Res 2002
(Cell Transformation, Viral) :
NF-kappaB inhibition
caused caspase 3 and 8 activation, PARP cleavage, and DNA fragmentation indicative of apoptosis
Chen et al., J Dent Res 2002
(Carcinoma, Squamous Cell...) :
Additionally, we found that the inhibition of
NFkappaB by Adv-SR-IkappaBalpha
enhanced TNF mediated
caspase-8 and -3 activation
Salmond et al., Eur J Immunol 2002
:
CD8+ T cell apoptosis induced by Escherichia coli heat-labile enterotoxin B subunit occurs via a novel pathway involving
NF-kappaB dependent
caspase activation
Schauvliege et al., J Biol Chem 2002
:
Transient transfections with caspase-11 promoter-luciferase reporter constructs and deletion/mutation analysis revealed an essential
role for
NF-kappaB binding in the up-regulation of
caspase-11 in response to LPS
Gumucio et al., Clin Exp Rheumatol 2002
(Autoimmune Diseases...) :
ASC itself participates in at least three important cellular processes : apoptosis, recruitment and activation of
pro-caspase-1 ( with associated processing and secretion of IL-1beta ), and
activation of
NF-kappaB ( a transcription factor involved in both initiation and resolution of the inflammatory response )
Shimada et al., Mol Carcinog 2002
(MAP Kinase Signaling System...) :
We found that
NFkappaB activation
inhibited c-jun NH ( 2 ) -terminal kinase and
caspase 3 activation induced by 4-HPR and that NFkappaB inhibition by the I kappa B alpha phosphorylation inhibitor compound Bay 117082 resulted in increasing sensitization of both PC-3 and DU145 lines to apoptosis induced by 4-HPR at low concentrations
Nitta et al., Cell Signal 2003
(Cell Transformation, Viral) :
Moreover, LMP1 induced
activation of
caspase-3 via the activation of
NF-kappaB
Shikama et al., Eur J Immunol 2003
:
Caspase-8 and
caspase-10 activate
NF-kappaB through RIP, NIK and IKKalpha kinases
Kim et al., Am J Physiol Gastrointest Liver Physiol 2003
(Helicobacter Infections) :
The suppression of
NF-kappaB significantly
increased caspase-3 activity and apoptosis in H. pylori infected MKN-45 and Hs746T gastric epithelial cell lines as well as primary gastric epithelial cells
Lagunoff et al., Int Rev Immunol 2003
:
Virally encoded genes inhibit the activation of
caspase-8 by the TNF receptor and Fas ; activate
NF-kappaB to
increase expression of antiapoptotic genes ; inhibit interferon response ; bind to p53, thereby blocking p53 dependent apoptosis ; and interact with other pro- and antiapoptotic cellular genes
Deng et al., Cell 2003
:
While activation of
caspase 8 is required for TNFalpha induced apoptosis, and induction of
NF-kappaB inhibits cell death, the precise function of JNK activation in TNFalpha signaling is not clearly understood
Cardoso et al., Free radical research 2003
(Alzheimer Disease) :
In this study, we analyzed if NF-kB activation prevented cells from caspases-activation and we also observed that inhibition of
NF-kB by PDTC
induced an increase in
caspase-3 and caspase-6 activation
Lamkanfi et al., J Biol Chem 2004
(MAP Kinase Signaling System) :
In contrast to pro-IL-1beta maturation,
caspase-1 induced
NF-kappaB activation is not inhibited by the virus derived caspase-1 inhibitor cytokine response modifier A and is equally induced by the enzymatically inactive caspase-1 C285A mutant ... We demonstrate that caspase-1 interacts with RIP2 and that dominant negative forms of RIP2 and IkappaB kinase complex-beta inhibit
caspase-1 mediated
NF-kappaB activation
Hentze et al., Hepatology 2004
:
CPT treatment completely abrogated the TNF induced
NF-kappa B activation, and mRNA expression of the antiapoptotic factors TNF-receptor associated factor 2, FLICE-inhibitory protein, and X-linked inhibitor of apoptosis protein was also
inhibited by CPT. The
caspase inhibitors benzyloxycarbonyl-Val-Ala-Asp- ( OMe ) -fluoromethylketone ( zVAD-fmk ) and benzyloxycarbonyl-Asp ( OMe ) -Glu ( OMe ) -Val-Asp ( OMe ) -chloromethylketone ( zDEVD-fmk ), as well as depletion of intracellular ATP by fructose prevented CPT/TNF induced apoptosis
Jiménez Del Río et al., Arch Med Res 2004
(Necrosis...) :
Further evaluations comprised production of H2O2, generation of hydroxyl radical ( .OH ), disruption of mitochondrial transmembrane potential ( DeltaPsim ),
caspase-3 activation, and
activation of
NF-kappaB and p53 transcriptional factors ... All metals induced mitochondrial depolarization ( 17-62 % nonfluorescent cells ) and
activated caspase-3 concomitantly with apoptotic morphology ( 25-32 % AO/EB ) at 24 h, and neither
NF-kappaB nor p53 transcription factor showed activation
Tantini et al., Amino Acids 2004
(MAP Kinase Signaling System) :
Moreover, pharmacological
NF-kappaB inhibition
reduced the increase in
caspase activity and cell death elicited by etoposide, suggesting that NF-kappaB is involved in signaling to apoptosis
Damiano et al., J Immunol 2004
:
NAIP CIIA HET-E and TP1 (NACHT) family proteins are involved in sensing intracellular pathogens or pathogen derived molecules, triggering host defense responses resulting in
caspase mediated processing of proinflammatory cytokines and
NF-kappaB activation
Lamkanfi et al., J Biol Chem 2005
:
Caspase-2 , unlike caspase-3, -6, -7, -9, -11, -12, and -14, is a potent
inducer of
NF-kappaB and p38 MAPK activation in a TRAF2 mediated way
Jun et al., Oncogene 2005
:
Role of FLASH in
caspase-8 mediated activation of
NF-kappaB : dominant negative function of FLASH mutant in NF-kappaB signaling pathway ... Here, we addressed the
role of endogenous
caspase-8 in tumor necrosis factor (TNF)-alpha induced activation of
NF-kappaB ... Instead,
caspase-8 ( D73A ) mutant bound to caspase-8 and
blocked NF-kappaB activation triggered by TNF-alpha and caspase-8 ... Taken together, these results suggest that endogenous
caspase-8 mediates TNF-alpha induced
activation of
NF-kappaB via FLASH
Moriuchi et al., Cancer Gene Ther 2005
(Brain Neoplasms...) :
Following infection with TOIkappaB, nuclear translocation of
NF-kappaB in U-87MG cells was significantly inhibited and
caspase-3 activity
increased compared with TOZ.1 infected cells
Hasegawa et al., J Biol Chem 2005
(Inflammation) :
ASC mediated
NF-kappaB activation leading to interleukin-8 production
requires caspase-8 and is inhibited by CLARP ... The catalytic activity of
caspase-8 was
required for the ASC mediated
NF-kappaB activation when caspase-8 was expressed at an endogenous level, although it was not essential when caspase-8 was overexpressed
Su et al., Science 2005
(Immunologic Deficiency Syndromes) :
Requirement for
caspase-8 in
NF-kappaB activation by antigen receptor
Dohrman et al., J Immunol 2005
:
Cellular FLIP ( long form ) regulates CD8+ T cell activation through
caspase-8 dependent
NF-kappa B activation
Cacicedo et al., Diabetes 2005
(Diabetic Retinopathy) :
Furthermore, inhibition of
NF-kappaB activation by various means
inhibited caspase-3 activation
Yip et al., J Bone Miner Res 2005
(Calcium Signaling) :
In this study, we showed a biphasic effect of TG on osteoclast formation and apoptosis through the regulation of ROS production,
caspase-3 activity, cytosolic Ca2+, and RANKL induced
activation of
NF-kappaB and AP-1 activities
Cavin et al., Mol Cancer Res 2005
(Carcinoma, Hepatocellular...) :
Lastly, we show that
NF-kappaB inhibits c-Myc induced activation of caspase-9 and
caspase-3 through up-regulation of the antiapoptotic target genes Bcl-X ( L ) and X-linked inhibitor of apoptosis (XIAP)
Tang et al., Cancer Biol Ther 2005
:
In the March 2005 issue of Science ( 2005 ; 307 : 1465-8 ), Su et al. provide compelling evidence supporting a
role for
caspase-8 in antigen receptor induced
NF-kappaB activation
Takahashi et al., Genes Cells 2005
(Pancreatic Neoplasms) :
We found that both
NF-kappaB activation and Bcl-2 family proteins could
prevent the 53BP2S mediated depression of mitochondrial transmembrane potential, activation of
caspase-9 , cleavage of poly ADP ribose polymerase ( PARP ), and cell death
Ma et al., J Biol Chem 2005
:
When
NF-kappaB activation was inhibited by a super-repressor, IkappaBalpha, the TLR4 ligand lipopolysaccharide
induced the activation of
caspase 8, the loss of mitochondrial transmembrane potential ( DeltaPsim ), and apoptotic cell death in macrophages
Albee et al., Inflamm Res 2006
(Inflammation) :
E. coli infection induces
caspase dependent degradation of
NF-kappaB and reduces the inflammatory response in macrophages ... Inhibition of
caspase activity
resulted in increased DNA binding activity of
NF-kappaB and enhanced production of NF-kappaB dependent reporter gene expression following infection ... Further, suppression of
caspase activity
reduced the proteolytic cleavage of
NF-kappaB ... These data indicate that infection of macrophages with E. coli induces a
caspase dependent inhibition of
NF-kappaB that results in a reduced production of pro-inflammatory cytokines and impaired clearance of bacteria
He et al., J Biol Chem 2006
:
TRAF6 regulates cell fate decisions by inducing
caspase 8-dependent apoptosis and the
activation of
NF-kappaB
Dieperink et al., Pediatr Res 2006
(Hyperoxia) :
Inhibition of
NF-kappaB prevented the hyperoxia induced activation of
caspase 3
Hu et al., Mol Cell Biol 2006
(Breast Neoplasms...) :
We found, however, that inhibiting
NF-kappaB significantly decreased ER stress induced cell death in a
caspase-8 dependent manner
Khera et al., Lab Invest 2006
:
Culture of cells in the presence of 25 mM D-glucose ( i ) enhanced apoptosis stimulated by serum depletion, ( ii ) enhanced activation of
caspase-3 , ( iii )
inhibited NF-kappaB activation, and ( iv ) decreased Bcl-2 : Bax ratio
Mohan et al., J Biol Chem 2006
(Colonic Neoplasms) :
The upstream activation of
caspase-2 is not
dependent on its antioxidant property or
NF-kappaB inhibition
Lamkanfi et al., J Cell Biol 2006
:
Caspases leave the beaten track :
caspase mediated activation of
NF-kappaB
Eisner et al., FEBS Lett 2006
:
We conclude that hyperosmotic stress activates p65 and RelB NFkappaB isoforms and
NFkappaB mediates
caspase 9 activation in cardiomyocytes
Wong et al., Clin Immunol 2006
:
The inhibition is caspase dependent since an inhibitor of
caspase activation, DEVD, can
block the suppression of
NF-kappaB activity following crosslinking of Fas
Han et al., Free Radic Biol Med 2006
:
The TNF induced apoptosis seems to occur only in a certain redox range -- in which redox changes can inhibit
NF-kappaB activity but not completely
inhibit caspase activity
Jiang et al., FASEB J 2006
(Colonic Neoplasms...) :
Stable expression of IKBSR, a known repressor of NF-kappaB activation, and cellular
caspase-8-like inhibitory protein ( cFLIP )
inhibited activation of
NF-kappaB in cancer cell media treated muscle cells with an accompanying enhancement of myogenic protein expression and differentiation
Kilpatrick et al., J Leukoc Biol 2006
(MAP Kinase Signaling System) :
delta-PKC associates with TNFR-1 in response to TNF and is required for
NFkappaB activation and
inhibition of
caspase 3
Oh et al., J Biomed Sci 2007
:
HeLa cells treated with phytoglycoprotein ( 150 kDa ) were killed by
activation of
caspase 3 via inhibitory activities of
NF-kappaB and AP-1
Lemmers et al., J Biol Chem 2007
(Rhabdoviridae Infections) :
Essential
role for
caspase-8 in Toll-like receptors and
NFkappaB signaling
Ou et al., Arch Toxicol 2007
:
Furthermore, several apoptotic signaling pathways which showed
NF-kappaB activation, increased cytosolic calcium, alteration of mitochondrial membrane potential, cytochrome c release and
activation of
caspase 3 were also investigated
Miggin et al., Proc Natl Acad Sci U S A 2007
:
NF-kappaB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is
regulated by
caspase-1 ... However, we found that Mal was cleaved by caspase-1 and that inhibition of
caspase-1 activity
blocked TLR2- and TLR4 mediated
NF-kappaB and p38 MAP kinase activation but not IL-1 or TLR7 signaling, which are Mal independent
He et al., Cell Signal 2007
:
NF-kappaB inhibition
enhances caspase-3 degradation of Akt1 and apoptosis in response to camptothecin ...
NF-kappaB inhibition by Pro1, dominant negative mutant IkappaBalpha ( S32/36 ) or p65 ( N250 ), however,
induced the
caspase-3 activation in the normal cells, indicating the role of ATM mediated NF-kappaB activation against cell apoptosis
Misra et al., J Biol Chem 2007
(Alstrom Syndrome) :
Consistent with this observation, inhibition of
caspase activity
attenuates NF-kappaB activation
Zhao et al., Exp Hematol 2007
(Lymphoma, B-Cell) :
In addition, SAHA induced IkappaBalpha cleavage to a stable inhibitory form and caused
NF-kappaB degradation in
response to
caspase-3 activation
Wang et al., Biochim Biophys Acta 2007
:
We further show that overexpression of
caspase-10g dramatically
enhances NF-kappaB activity in a dose- and time dependent manner
Cruz et al., Infect Immun 2008
(Inflammation...) :
Our combined results demonstrate that B. burgdorferi confined to phagolysosomes is a potent inducer of cytosolic signals that result in ( i ) production of
NF-kappaB dependent cytokines, ( ii ) assembly of the inflammasome and activation of
caspase-1 , and ( iii ) induction of programmed cell death
Lee et al., Mol Cancer Ther 2007
(Colonic Neoplasms) :
In addition,
caspase-3 inhibitor
reduced epothilone B-induced cell death and
NF-kappaB activation
Bhoopathi et al., J Biol Chem 2008
(MAP Kinase Signaling System...) :
ERK inhibition, using a kinase-dead mutant for ERK, ameliorated
NF-kappaB activation and
caspase mediated apoptosis in Ad-MMP-9 infected cells
Kersse et al., Biochem Soc Trans 2007
(Inflammation) :
Furthermore, we discuss the functional characteristics of the caspase-1 related CARD-only proteins in relation to
caspase-1 mediated IL-1beta maturation and
NF-kappaB activation
Lakshmanan et al., J Immunol 2007
:
Because a specific NF-kappaB inhibitor blocked LPS induced IL-8 and CCL4 mRNA expression as well as IL-8 and CCL4 secretion in THP1 cells, we investigated the
role of
caspase-4 in
NF-kappaB signaling
Hinshaw-Makepeace et al., Eur J Immunol 2008
:
Effective stimulation of
NF-kappaB in T cells following TCR ligation
requires the activity of
caspase-8
Chuang et al., In Vivo 2007
(Uterine Cervical Neoplasms) :
Coumarin induces cell cycle arrest and apoptosis in human cervical cancer HeLa cells through a mitochondria- and
caspase-3 dependent mechanism and
NF-kappaB down-regulation
Gartner et al., Vaccine 2008
:
Transient transfection showed that the mutated
caspase induced slow apoptosis, normal protein expression and
NF-kappaB activation while wild-type caspase induced rapid apoptosis, lower protein expression and no NF-kappaB activation
Al-Lamki et al., J Am Soc Nephrol 2008
(Nephritis) :
Inhibition of
NF-kappaB activation
increased TL1A mediated
caspase-3 activation and apoptosis of TEC, but it did not reduce the induction of TNFR2
Ballaun et al., Biochem Biophys Res Commun 2008
:
Transcription of the
caspase-14 gene in human epidermal keratinocytes
requires AP-1 and
NFkappaB ... Our data reveal the basic organization of the human caspase-14 promoter and suggest an important
role of AP-1 and
NFkappaB in the transcriptional control of
caspase-14
Bren et al., PloS one 2008
(Alstrom Syndrome) :
Given the independent observations that acute T cell HIV-1 infection results in ( 1 ) NF-kappaB activation, ( 2 ) caspase 8 dependent apoptosis, and that ( 3 )
caspase 8 directly
activates NF-kappaB , we questioned whether these three events might be interrelated ... Finally, we demonstrate that the HIV protease cleavage of
caspase 8 is
necessary for optimal
NF-kappaB activation and that the HIV-1 protease specific cleavage fragment Casp8p41 is sufficient to stimulate HIV-1 replication through NF-kappaB dependent HIV-LTR activation both in vitro as well as in cells from HIV infected donors
Kin et al., Shock 2008
:
Compared with Control, Postcon also inhibited translocation of
NF-kappa B to nuclei ( 167 % +/- 21 % vs. 142 % +/- 18 % * ), decreased the level of plasma TNF-alpha ( 1,994 +/- 447 vs. 667 +/- 130* pg/mL ), and
inhibited caspase-3 activity ( 0.57 % +/- 0.1 % vs. 0.21 % +/- 0.1 % * )
Chae et al., Blood 2008
(Familial Mediterranean Fever) :
The familial Mediterranean fever protein, pyrin, is cleaved by
caspase-1 and
activates NF-kappaB through its N-terminal fragment
Bednarski et al., Mol Cancer Ther 2008
:
The inhibition of doxorubicin induced
NF-kappaB activation by the knockdown of either catalytic subunit
resulted in increased cleaved
caspase-3 and cleaved poly ( ADP-ribose ) polymerase and increased apoptosis when compared with doxorubicin alone
Pacheco-Palencia et al., J Agric Food Chem 2008
(Skin Diseases) :
Pomegranate extract ( PE ), in a range from 5 to 60 mg/L, was effective at protecting human skin fibroblasts from cell death following UV exposure, likely related to a reduced
activation of the pro-inflammatory transcription factor
NF-kappaB , a downregulation of proapoptotic
caspase-3 , and an increased G0/G1 phase, associated with DNA repair
Maelfait et al., Biochem Pharmacol 2008
:
Here we review the
role of
caspase-8 in embryonic development, monocyte differentiation, T and B cell proliferation, and the activation of
NF-kappaB
Moon et al., Cancer Lett 2009
(Neoplasms) :
Sulforaphane suppresses TNF-alpha mediated activation of
NF-kappaB and
induces apoptosis through activation of reactive oxygen species dependent
caspase-3 ... In conclusion, the results of the present study indicate that SFN suppresses TNF-alpha induced
NF-kappaB activity and
induces apoptosis through activation of ROS dependent
caspase-3
Zhang et al., Clin Exp Pharmacol Physiol 2009
(Adrenal Gland Neoplasms...) :
The inhibition of
NF-kappaB by TPCK
enhanced caspase 3 activity induced by 300 micromol/L H(2)O ( 2 )
Mustonen et al., Dig Dis Sci 2009
:
Taurocholate potentiates ethanol induced
NF-kappaB activation and
inhibits caspase-3 activity in cultured rat gastric mucosal cells
Ge et al., Biol Reprod 2009
:
On the other hand, inhibition of EGFR, Ca ( 2+ ) /PKC, or
NFKB1 abolished the EGF stimulated increase in the expression of cyclins CCND1 and CCNE1, cyclin dependent kinase 6 (CDK6), CDK2, and BCL2, and
restored the EGF induced inhibition of BAX expression and
caspase 3/9 activity, indicating that EGFR, PKC, and NFKB1 signaling cascades were involved in EGF stimulated DNA synthesis and antiapoptosis action
Kim et al., Bone 2009
(Bone Resorption) :
Furthermore, Western blotting showed that HSP60 up-regulated TLR-2 and TLR-4 expression, and pretreatment with blocking antibodies for TLR-2 and TLR-4 almost completely eliminated the effects of HSP60 on apoptosis,
caspase-3 and -9 activation, and
activation of
NFkappaB and p38 MAPK
Shan et al., Mol Cell Biochem 2009
:
Interestingly, our data demonstrated that RIOK3 suppressed
caspase-10 mediated
NF-kappaB activation by competing RIP1 and NIK to bind to caspase-10
Montecucco et al., J Biomed Biotechnol 2009
(Inflammation) :
Oxaprozin pro-apoptotic activity was associated with the inhibition of CD40L triggered Akt and
NF-kappaB phosphorylation and the
activation of
caspase 3
Connelly et al., J Cell Physiol 2010
(Disease Models, Animal...) :
We found that activation of
NF-kappaB during involution resulted in a more rapid reduction in milk levels and
increased cleavage of
caspase-3 , an indicator of apoptosis
Harder et al., J Immunol 2009
(Disease Models, Animal...) :
These results indicate that
caspase-1 activation in response to S. pyogenes infection
requires NF-kappaB and the virulence factor streptolysin O, but proceeds independently of P2X7R and TLR signaling
Henrotin et al., Osteoarthritis Cartilage 2010
(Inflammation...) :
Curcumin blocks IL-1beta induced proteoglycan degradation,
AP-1/NF-kappaB signalling, chondrocyte apoptosis and
activation of
caspase-3
Chang et al., Experimental biology and medicine (Maywood, N.J.) 2009
:
The proteolytic activity of
caspase 8 was
required for the
NF-kappaB activity
Roccaro et al., Blood 2010
(Lymphoma...) :
Primary WM cells express higher level of i20S compared with c20S, and that ONX0912 inhibited the CT-L activity of both i20S and c20S, leading to induction of toxicity in primary WM cells, as well as of apoptosis through c-Jun N-terminal kinase activation,
nuclear factor kappaB (NF-kappaB) inhibition ,
caspase cleavage, and initiation of the unfolded protein response
Park et al., Toxicol In Vitro 2010
(Carcinoma, Squamous Cell...) :
These findings collectively suggest that aspirin induces apoptosis in YD-8 cells and the induction may be correlated to activation of caspases,
caspase dependent Mcl-1 proteolysis, inactivation of ERK-1/2 and AKT, and
activation of
NF-kappaB
Liang et al., Zhongguo Shi Yan Xue Ye Xue Za Zhi 2010
:
The expression levels of
caspase-3 and bax after co-treatment of GA and Fe3O4-MNP were higher than that exposed to GA or Fe3O4-MNP alone, but the expressions of bcl-2,
NF-kappaB and survivin were
down-regulated
Ehrenschwender et al., Cell Death Differ 2010
(Neoplasm Invasiveness) :
NFkappaB activation and adoption of amoeboid shape were inhibited by caspase-8 knockdown or FLIP-S expression, but only the cell morphology alterations
required caspase-8 activity
Li et al., Zhongguo Shi Yan Xue Ye Xue Za Zhi 2010
:
The mechanism of apoptosis may be related to the down-regulation of the expression of
NF-kappaB and the
activation of
caspase 3
Wang et al., Microb Pathog 2010
:
Collectively, these data define a pathway that infection of primary monocytes and U937 cells with S. aureus induces a
caspase dependent inhibition of
NF-kappaB
Wu et al., Biochem Cell Biol 2010
(Carcinoma, Hepatocellular...) :
Inhibition of
NF-kappaB by PDTC decreased NF-kappaB p65 expression, enhanced cell apoptosis ratio, and
increased caspase-3 activity
Gentle et al., J Biol Chem 2011
:
In TNF stimulated cells, RIPK1 promotes cell survival by stabilizing TRAF2 and cIAP1, which limits induction of non-canonical
NF-kappaB and
activation of
caspase-8
Langone et al., Int J Cancer 2012
(Brain Neoplasms...) :
Furthermore, overexpression of
NF-kB in the B16F10 cells
blocked adduct evoked stimulation of
caspase-3/7 activity