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NUP214 — RAN

Pathways - manually collected, often from reviews:

• BioCarta sumoylation by ranbp2 regulates transcriptional repression: NPC complex (RANBP2-NUP214-NUP210-NUP62-NUP153) → Ran/GTP/Exportin/HDAC4 complex (RAN-HDAC4) (translocation, activates)
  
• BioCarta sumoylation by ranbp2 regulates transcriptional repression: NPC complex (RANBP2-NUP214-NUP210-NUP62-NUP153) → Ran/GTP/Exportin/HDAC6 complex (RAN-HDAC6) (translocation, activates)
  
• BioCarta sumoylation by ranbp2 regulates transcriptional repression: NPC complex (RANBP2-NUP214-NUP210-NUP62-NUP153) → Ran/GTP/Exportin/MITR complex (RAN-HDAC9) (translocation, activates)
  
• BioCarta cycling of ran in nucleocytoplasmic transport: NPC complex (RANBP2-NUP214-NUP210-NUP62-NUP153) → Ran/GDP/Cargo/Importin complex (RAN) (translocation, activates)
  
• BioCarta mechanism of protein import into the nucleus: NPC complex (RANBP2-NUP214-NUP210-NUP62-NUP153) → Cargo/Importin-alpha/Ran/GDP/Importin-beta/NTF2 complex (KPNA2-RAN-KPNB1-NUTF2) (translocation, activates)
  
• NCI Pathway Database Signaling events mediated by HDAC Class II: NPC complex (RANBP2-NUP214-NUP210-NUP62-NUP153) → Ran/GTP/Exportin 1/HDAC4 complex (RAN-XPO1-HDAC4) (translocation, activates)
  
• NCI Pathway Database Sumoylation by RanBP2 regulates transcriptional repression: NPC complex (RANBP2-NUP214-NUP210-NUP62-NUP153) → Ran/GTP/Exportin 1/HDAC4 complex (RAN-XPO1-HDAC4) (translocation, activates)
  
• NCI Pathway Database Sumoylation by RanBP2 regulates transcriptional repression: NPC/RanGAP1/SUMO1/RanBP2/Ubc9 complex (RANGAP1-SUMO1-RANBP2-UBE2I-NUP62-NUP210-NUP214-NUP153) → Ran/GTP/Exportin 1 complex (RAN-XPO1) (modification, activates)
  Askjaer et al., Mol Cell Biol 1999
  Evidence: assay
• NCI Pathway Database Sumoylation by RanBP2 regulates transcriptional repression: NPC/RanGAP1/SUMO1/RanBP2/Ubc9 complex (RANGAP1-SUMO1-RANBP2-UBE2I-NUP62-NUP210-NUP214-NUP153) → Ran/GTP complex (RAN) (modification, activates) Askjaer et al., Mol Cell Biol 1999
  Evidence: assay
• NCI Pathway Database Role of Calcineurin-dependent NFAT signaling in lymphocytes: Exportin 1/Ran/NUP214 complex (XPO1-RAN-NUP214) → NFATc (NFATC1) (translocation, activates) Hutten et al., Mol Cell Biol 2006*, Beals et al., Science 1997*, Kehlenbach et al., J Cell Biol 1998*
  Evidence: mutant phenotype, assay
• NCI Pathway Database Sumoylation by RanBP2 regulates transcriptional repression: NPC/RanGAP1/SUMO1/RanBP2/Ubc9 complex (RANGAP1-SUMO1-RANBP2-UBE2I-NUP62-NUP210-NUP214-NUP153) → Ran/GTP/Exportin 1 complex (RAN-XPO1) (modification, activates)
  Kirsh et al., EMBO J 2002
  Evidence: assay
• NCI Pathway Database Sumoylation by RanBP2 regulates transcriptional repression: NPC/RanGAP1/SUMO1/RanBP2/Ubc9 complex (RANGAP1-SUMO1-RANBP2-UBE2I-NUP62-NUP210-NUP214-NUP153) → Ran/GTP/Exportin 1/HDAC4 complex (RAN-XPO1-HDAC4) (modification, activates)
  Kirsh et al., EMBO J 2002
  Evidence: assay
• NCI Pathway Database Signaling events mediated by HDAC Class I: NPC/RanGAP1/SUMO1/Ubc9 complex (RANGAP1-SUMO1-UBE2I-NUP62-RANBP2-NUP210-NUP214-NUP153) → Ran/GTP/Exportin 1 complex (RAN-XPO1) (modification, activates)
  David et al., J Biol Chem 2002, Colombo et al., EMBO Rep 2002
  Evidence: assay
• NCI Pathway Database Signaling events mediated by HDAC Class I: NPC/RanGAP1/SUMO1/Ubc9 complex (RANGAP1-SUMO1-UBE2I-NUP62-RANBP2-NUP210-NUP214-NUP153) → Ran/GTP/Exportin 1/HDAC1 complex (RAN-XPO1-HDAC1) (modification, activates)
  David et al., J Biol Chem 2002, Colombo et al., EMBO Rep 2002
  Evidence: assay
• NCI Pathway Database Sumoylation by RanBP2 regulates transcriptional repression: NPC/RanGAP1/SUMO1/RanBP2/Ubc9 complex (RANGAP1-SUMO1-RANBP2-UBE2I-NUP62-NUP210-NUP214-NUP153) → Ran/GTP/Exportin 1 complex (RAN-XPO1) (modification, activates)
  David et al., J Biol Chem 2002, Colombo et al., EMBO Rep 2002
  Evidence: assay
• NCI Pathway Database Sumoylation by RanBP2 regulates transcriptional repression: NPC/RanGAP1/SUMO1/RanBP2/Ubc9 complex (RANGAP1-SUMO1-RANBP2-UBE2I-NUP62-NUP210-NUP214-NUP153) → Ran/GTP/Exportin 1/HDAC1 complex (RAN-XPO1-HDAC1) (modification, activates)
  David et al., J Biol Chem 2002, Colombo et al., EMBO Rep 2002
  Evidence: assay
• NCI Pathway Database Signaling events mediated by HDAC Class II: NPC/RanGAP1/SUMO1/Ubc9 complex (RANGAP1-SUMO1-UBE2I-NUP62-RANBP2-NUP210-NUP214-NUP153) → Ran/GTP/Exportin 1 complex (RAN-XPO1) (modification, activates)
  Kirsh et al., EMBO J 2002
  Evidence: assay
• NCI Pathway Database Signaling events mediated by HDAC Class II: NPC/RanGAP1/SUMO1/Ubc9 complex (RANGAP1-SUMO1-UBE2I-NUP62-RANBP2-NUP210-NUP214-NUP153) → Ran/GTP/Exportin 1/HDAC4 complex (RAN-XPO1-HDAC4) (modification, activates)
  Kirsh et al., EMBO J 2002
  Evidence: assay
• Reactome Reaction: NUP214 → RAN (indirect_complex)
• Reactome Reaction: NUP214 → RAN (reaction) Yi et al., J Virol 2002, Robb et al., Nature structural & molecular biology 2005, Ohrt et al., Nucleic Acids Res 2008, Weinmann et al., Cell 2009, Ahlenstiel et al., Nucleic Acids Res 2012, Nishi et al., RNA 2013, Doyle et al., RNA 2013, Gagnon et al., Cell reports 2014, Wei et al., J Biol Chem 2014, Meyer et al., Genes Dev 1994, Görlich et al., J Cell Biol 1997

Text-mined interactions from Literome

Kuersten et al., Mol Cell Biol 2002 : The N terminus binds to both Nup153 and RanBP2/Nup358 in a RanGTP dependent manner, while the C terminus binds to CAN/Nup214 independently of Ran
Dingwall et al., Proc Natl Acad Sci U S A 1995 : These data identify Nup2p as a target for Ran in the nuclear pore complex, suggesting a direct role for it in nuclear-cytoplasmic transport