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RELA — TGFB1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Eickelberg et al., J Biol Chem 1999
:
In contrast, neither CCAAT enhancer binding protein-beta,
NF-kappaB , nor Sp1 were
activated by
TGF-beta1
Seppänen et al., Oncol Res 1998
(Adenocarcinoma...) :
In the present study, we have investigated the
effects of interferons-alpha (IFN-alpha) and -gamma ( IFN-gamma ), interleukin-10 (IL-10) and -13 ( IL-13 ),
transforming growth factor-beta1 ( TGF-beta1 ), granulocyte-macrophage colony stimulating factor ( GM-CSF ), and tumor necrosis factor-alpha (TNF-alpha) on cell proliferation and induction of transcription factors AP-1 and
NF-kappaB in UM-EC-3 human endometrial adenocarcinoma cells and UT-OC-5 ovarian carcinoma cells in vitro
Hu et al., J Leukoc Biol 1999
:
Anti-inflammatory cytokines, IL-10, and
transforming growth factor ( TGF ) -beta sequentially
inhibited LPS- and cytokine induced microglial cell
NF-kappaB activation, RANTES mRNA expression, and protein release
Azuma et al., Exp Cell Res 1999
:
TGF-beta1 inhibits
NF-kappaB activity through induction of IkappaB-alpha expression in human salivary gland cells : a possible mechanism of growth suppression by TGF-beta1 ... Because NF-kappaB is not only involved in inflammatory responses but also mediates cell growth, we have investigated the
effect of
TGF-beta1 on the activity of
NF-kappaB and the role of the inhibitory IkappaB-alpha protein in the growth of the human salivary gland cell clones NS-SV-AC, HSGc, and cl-1 ... These results indicate that
TGF-beta1 downregulates NF-kappaB activity through the induction of IkappaB-alpha expression in human salivary gland cells and that inhibition of
NF-kappaB activity
suppresses the growth rate of these cells
Andoh et al., Pancreas 2000
(Pancreatic Neoplasms) :
In PANC-1 cells, IL-1beta and TNF-alpha induced a rapid activation of
nuclear factor (NF)-kappaB , and
TGF-beta1 enhanced this activation slightly
Yeung et al., Mol Cell Biol 2001
:
RKIP physically interacted with four kinases of the NF-kappaB activation pathway,
NF-kappaB inducing kinase,
transforming growth factor beta activated kinase 1, IKKalpha, and IKKbeta
Loukinova et al., Int J Cancer 2001
(Carcinoma, Squamous Cell...) :
In our study, we investigated the
effect of the regulatory cytokines, IL-1alpha, EGF and
TGF-beta1 on activation of
NF-kappaB and Gro1 in primary and metastatic sublines of the murine SCC Pam 212
Díez-Fernández et al., Free Radic Biol Med 2002
:
Heat treatment also prevented
TGF-beta1 induced activation of
nuclear factor kappa B (NF-kappaB) by preventing the degradation of the inhibitory protein kappa Balpha ( IkappaBalpha )
Arsura et al., Oncogene 2003
(Carcinoma, Hepatocellular...) :
Transient
activation of
NF-kappaB through a TAK1/IKK kinase pathway by
TGF-beta1 inhibits AP-1/SMAD signaling and apoptosis : implications in liver tumor formation ... Here we elucidate the mechanism of
TGF-beta1 mediated regulation of
NF-kappaB and induction of apoptosis in epithelial cells
Haller et al., J Biol Chem 2003
(Bacteroides Infections) :
Transforming growth factor-beta 1 inhibits non-pathogenic Gram negative bacteria induced
NF-kappa B recruitment to the interleukin-6 gene promoter in intestinal epithelial cells through modulation of histone acetylation ... Interestingly,
TGF-beta1 inhibited B. vulgatus- and lipopolysaccharide (LPS) induced
NF-kappaB transcriptional activity as well as interleukin-6 (IL-6) mRNA accumulation and protein secretion in IEC ... Adenoviral delivery of Smad7 and dominant negative Smad3 ( SmadDelta3 ) reversed the
TGF-beta1 mediated inhibition of
NF-kappaB transcriptional activity and NF-kappaB recruitment to the IL-6 promoter
Sola et al., J Biol Chem 2003
:
In addition, UDCA inhibited
TGF-beta1 induced degradation of
nuclear factor kappaB (NF-kappaB) and its inhibitor IkappaB ( p < 0.05 )
Lan et al., Chin Med J (Engl) 2004
:
NF-kappa B may be
involved in the enhancement of
TGF-beta 1 induced by Ox-LDL in rat mesangial cells
Zafiriou et al., Kidney Int 2004
(Fibrosis...) :
LDL induced increases in MCP-1 and
TGF-beta1 were
independent of
nuclear factor-kappaB (NF-kappaB) transcriptional activity
Kim et al., J Immunol 2004
:
In contrast,
TGF-beta1 and LY294002
enhanced LPS induced
NF-kappaB activity
Rödel et al., Int J Radiat Biol 2004
:
The
induction by
NF-kappaB of
TGF-beta1 in endothelial cells might contribute to the anti-inflammatory properties of low-dose ionizing irradiation
Le et al., J Immunol 2004
:
These
effects of
TGF-beta1 culminate in the inhibition of LPS induced activation of
NF-kappaB and the up-regulation of FPR2 in microglial cells
Odabaei et al., Adv Cancer Res 2004
(MAP Kinase Signaling System) :
RKIP has been shown to disrupt the Raf-1-MEK1/2 [ mitogen activated protein kinase-ERK ( extracellular signal regulated kinase ) kinase-1/2 ] -ERK1/2 and NF-kappaB signaling pathways, via physical interaction with Raf-1-MEK1/2 and
NF-kappaB inducing kinase or
transforming growth factor beta activated kinase-1, respectively, thereby abrogating the survival and antiapoptotic properties of these signaling pathways
Mauviel et al., Curr Biol 1993
:
We demonstrate that
transforming growth factor-beta ( TGF-beta ) does not interfere with cytokine induced IL-8 gene expression, nor does it
affect the activity of
NF-kappaB-driven promoters
Seabra et al., Biochem Biophys Res Commun 2004
(Inflammation) :
TGF-beta1 led to inducible nitric oxide synthase (iNOS) degradation, actin filament ( F-actin ) depolymerization, and lack of
nuclear factor-kappaB (NF-kappaB) in the nucleus
Dheen et al., Glia 2005
(Neurodegenerative Diseases) :
The anti-inflammatory effects of RA were correlated with the enhanced expression of retinoic acid receptor-beta, and
transforming growth factor-beta1 as well as the
inhibition of
NF-kappaB translocation
Naiki et al., J Biol Chem 2005
:
In this study we show that
TGF-beta1 blocks the
NF-kappaB activation and cytokine release that is stimulated by ligands for TLRs 2, 4, and 5
König et al., J Cell Biol 2005
:
Overexpression of a constitutively active ALK1 mimicked the
effect of
TGF-beta1 on
NF-kappaB activation and neuroprotection ... Our data suggest that
TGF-beta1 simultaneously activates two distinct receptor pathways in neurons and that the ALK1 pathway
mediates TGF-beta1 induced
NF-kappaB survival signaling
Komura et al., Cancer Res 2005
(Primary Myelofibrosis) :
The regulation of
TGF-beta1 synthesis is poorly known but seems
regulated by
nuclear factor kappaB (NF-kappaB) ... The expression of an NF-kappaB superrepressor in FKBP51 overexpressing cells and in derived megakaryocytes from CD34 ( + ) of IMF patients revealed that
NF-kappaB activation was not
involved in the resistance to apoptosis after cytokine deprivation of these cells but in
TGF-beta1 secretion
Kaur et al., J Biol Chem 2005
(Carcinoma, Hepatocellular) :
In addition,
induction of
NF-kappaB by
TGF-beta1 inhibits JNK signaling, thereby attenuating TGF-beta1 induced cell death of normal hepatocytes
Grau et al., Cell Signal 2006
(Colonic Neoplasms) :
Smad4 restores the
TGF-beta-1 mediated
NF-kappaB activation in SW480 cells
Lee et al., J Immunol 2006
:
Our results suggest that IL-1beta stimulated transcription of
TGF-beta1 is temporally
regulated by
NF-kappaB and AP-1 and involves histone hyperacetylation at distinct promoter sites
Ji et al., World J Gastroenterol 2006
(Carcinoma, Hepatocellular...) :
NF-kappaB may
cause activation and production of
TGF-beta1
Cho et al., Immunol Lett 2006
(Arthritis, Rheumatoid...) :
TGF-beta1 blocked the degradation of cytosolic IkappaB-alpha and the translocation of activated
NF-kappaB to the nucleus
Harding et al., Kidney Int 2006
:
TGFbeta1 increased transcription by approximately 50 % and
activated both AP-1 and
NF-kappaB
Ishinaga et al., EMBO J 2007
(Haemophilus Infections) :
Here, we show that
TGF-beta1 induces acetylation of NF-kappaB p65 subunit to synergistically enhance bacterium nontypeable Haemophilus influenzae induced
NF-kappaB activation and inflammatory response in vitro and in vivo
Xie et al., Am J Physiol Lung Cell Mol Physiol 2007
(Asthma...) :
The mitogenic activity of
TGF-beta1 on ASM cells was
inhibited by selective inhibitors of TGF-beta receptor I kinase ( SD-208 ), phosphatidylinositol 3-kinase ( PI3K, LY-294002 ), ERK ( PD-98059 ), JNK ( SP-600125 ), and
NF-kappaB ( AS-602868 ) ...
NF-kappaB is also
involved in the
TGF-beta1 mitogenic signaling, but Smad pathway does not appear important
Neil et al., Cancer Res 2008
(Disease Progression) :
Altered TAB1 :
I kappaB kinase interaction
promotes transforming growth factor beta mediated nuclear factor-kappaB activation during breast cancer progression
Ishinaga et al., Biochem J 2009
:
TGF-beta1 synergistically
enhances TNF-alpha induced
NF-kappaB DNA binding activity via induction of RelA acetylation
Minakawa et al., Biol Pharm Bull 2008
:
In this study, we examined the effect of ISGylation on tumor necrosis factor receptor associated factor ( TRAF)
6/transforming growth factor beta activated kinase ( TAK)-1 dependent
NF-kappaB activation
Miller et al., Mol Cell Biol 1991
:
In 70Z/3 cells,
transforming growth factor beta , an inhibitor of kappa-gene induction,
blocks the upregulation of Oct-2 but not the activation of
NF-kappa B
Lo et al., J Cell Physiol 2009
:
These cells were then stimulated with a high glucose concentration to modulate ANP, TGF-beta1, collagen type I, NF-kappaB and IkappaB-alpha, and the results showed that ANP, TGF-beta1, collagen type I and
NF-kappaB significantly increased in untransfected cells, and the transfection of ANP significantly
attenuated high glucose activated
TGF-beta1 , collagen I and NF-kappaB expression
Cohen et al., Cancer Res 2009
(Carcinoma, Squamous Cell...) :
However, in HNSCC cells that retained residual TGFbeta signaling,
TGFbeta1 inhibited both constitutive and tumor necrosis factor alpha stimulated
NF-kappaB activity
Cho et al., American journal of physiology. Renal physiology 2009
(Disease Models, Animal...) :
The untreated CKD rats exhibited azotemia, hypertension, hypertriglyceridemia, proteinuria, glomerulosclerosis, tubulointerstitial damage, upregulation of MCP-1, plasminogen activator inhibitor-1 ( PAI-1 ),
transforming growth factor ( TGF ) -beta , cyclooxygenase (COX)-1, COX-2, and NAD ( P ) H oxidase ( NOX-4, gp91(phox), p47(phox) and p22(phox) subunits ) and
activation of
NF-kappaB ( IkappaB phosphorylation )
Shi et al., Sichuan Da Xue Xue Bao Yi Xue Ban 2009
:
To investigate the expression of CTGF, CTGF mRNA,
NF-kappaB and AP-1
induced by
TGF-beta1 in human lung fibroblast ( HLF-02 ), and study the effect and possible mechanism of rosiglitazone on signal pathways of TGF-beta1 in HLF-02 ... The
effects of
TGF-beta1 , curcumin, PDTC and rosiglitazone on the expression of CTGF,
NF-kappaB and AP-1 were evaluated with Western blot
Tobar et al., Mol Cell Biochem 2010
:
We found that
TGF-beta1 activates
NFkappaB , through Rac1-NOXs-ROS dependent mechanism ... Our results shows that
TGF-beta1 stimulation of uPA and MMP-9 expression
involve NOXs dependent ROS and
NFkappaB , activation, demonstrated by using DPI, NOXs inhibitor, ROS scavenger N-acetylcysteine and SN50, an NFkb inhibitor
Kwon et al., J Endod 2010
:
However,
TGFbeta1 did not
affect Akt/NF-kappaB signaling to regulate the migration of MDPC-23 cells
Arsura et al., Immunity 1996
:
TGF beta 1 inhibits
NF-kappa B/Rel activity inducing apoptosis of B cells : transcriptional activation of I kappa B alpha
Jeon et al., Toxicol Appl Pharmacol 1997
:
Conversely,
NF-kappa B/Rel binding activity was inhibited on Days 2 through 4 in sRBC sensitized splenocytes in the
presence of
TGF-beta 1
Hong et al., J Immunol 1997
:
These results indicate that the generation of H2O2 and
activation of
NF-kappaB by
TGF-beta1 are required for the induction of M-CSF gene transcription
Han et al., J Pharmacol Exp Ther 1998
:
Under identical condition, we examined the
effect of
TGF-beta1 on the activity of nuclear factor AT ( NF-AT ),
nuclear factor kappaB (NF-kappaB) , activator protein-1 (AP-1) and octamer, all of which contribute to the regulation of IL-2 gene expression ... Electrophoretic mobility shift assays showed that
TGF-beta1 markedly
increased NF-AT,
NF-kappaB and AP-1 binding to their respective cognate DNA binding sites, whereas octamer binding remained constant, as compared with untreated cells