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CSF2RB — IL3

Pathways - manually collected, often from reviews:

• BioCarta il 3 signaling pathway: IL-3/IL-3R-alpha/IL-3R-beta/JAK2 complex (JAK2-CSF2RB-IL3RA-IL3) → STAT5 (STAT5A/STAT5B) (modification, activates)
• BioCarta il 3 signaling pathway: IL-3/IL-3R-alpha/IL-3R-beta/JAK2 complex (JAK2-CSF2RB-IL3RA-IL3) → SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1) (modification, activates)
  
• BioCarta il 3 signaling pathway: IL-3/IL-3R-alpha/IL-3R-beta/JAK2 complex (JAK2-CSF2RB-IL3RA-IL3) → JAK2 (modification, collaborate)
• BioCarta il 3 signaling pathway: IL-3/IL-3R-alpha/IL-3R-beta/JAK2 complex (JAK2-CSF2RB-IL3RA-IL3) → IL-3/IL-3R-alpha/IL-3R-beta complex (IL3RA-IL3-CSF2RB) (modification, collaborate)
  
• BioCarta il 3 signaling pathway: SHP-1 (PTPN6) → IL-3/IL-3R-alpha/IL-3R-beta complex (IL3RA-IL3-CSF2RB) (modification, inhibits)
  
• BioCarta il 3 signaling pathway: JAK2 → IL-3/IL-3R-alpha/IL-3R-beta complex (IL3RA-IL3-CSF2RB) (modification, collaborate)
  
• BioCarta il 3 signaling pathway: IL-3 (IL3) → IL-3R-alpha/IL-3R-beta complex (CSF2RB-IL3RA) (modification, collaborate)
  
• BioCarta il 3 signaling pathway: IL-3 (IL3) → IL-3/IL-3R-alpha/IL-3R-beta complex (IL3RA-IL3-CSF2RB) (modification, collaborate)
  
• BioCarta il 3 signaling pathway: IL-3R-alpha/IL-3R-beta complex (CSF2RB-IL3RA) → IL-3/IL-3R-alpha/IL-3R-beta complex (IL3RA-IL3-CSF2RB) (modification, collaborate)
  
• BioCarta regulation of bad phosphorylation: IL-3 (IL3) → IL-3R complex (IL3RA-CSF2RB) (modification, collaborate)
  
• BioCarta regulation of bad phosphorylation: IL-3 (IL3) → IL-3R-alpha/Colony stimulating factor 2 receptor beta/IL-3 complex (IL3RA-CSF2RB-IL3) (modification, collaborate)
  
• BioCarta regulation of bad phosphorylation: IL-3R complex (IL3RA-CSF2RB) → IL-3R-alpha/Colony stimulating factor 2 receptor beta/IL-3 complex (IL3RA-CSF2RB-IL3) (modification, collaborate)
  
• KEGG Apoptosis: IL3 → CSF2RB/IL3RA (protein-protein, activation)
• KEGG Cytokine-cytokine receptor interaction: IL3 → Complex of CSF2RB-IL3RA (protein-protein, activation)
• NCI Pathway Database IL3-mediated signaling events: IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC complex (CSF2RB-JAK2-SHC1-IL3-IL3RA) → SHIP (INPP5D) (modification, collaborate) Bone et al., Cell Signal 2000, Damen et al., Proc Natl Acad Sci U S A 1996, Lioubin et al., Genes Dev 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL3-mediated signaling events: IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC complex (CSF2RB-JAK2-SHC1-IL3-IL3RA) → IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC/SHIP complex (CSF2RB-JAK2-SHC1-INPP5D-IL3-IL3RA) (modification, collaborate)
  Bone et al., Cell Signal 2000, Damen et al., Proc Natl Acad Sci U S A 1996, Lioubin et al., Genes Dev 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL3-mediated signaling events: SHIP (INPP5D) → IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC/SHIP complex (CSF2RB-JAK2-SHC1-INPP5D-IL3-IL3RA) (modification, collaborate)
  Bone et al., Cell Signal 2000, Damen et al., Proc Natl Acad Sci U S A 1996, Lioubin et al., Genes Dev 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL3-mediated signaling events: IL3/IL3RA/CSF2RB (dodecamer)/YWHAZ/SHC complex (CSF2RB-YWHAZ-SHC1-IL3-IL3RA) → PI3K complex (PIK3CA-PIK3R1) (modification, activates)
  Barry et al., J Biol Chem 2009, Gold et al., J Biol Chem 1994, Sato et al., EMBO J 1993
  Evidence: mutant phenotype, assay
• NCI Pathway Database IL3-mediated signaling events: IL3/IL3RA/CSF2RB (hexamer) complex (CSF2RB-IL3-IL3RA) → CSF2RB (dimer) complex (CSF2RB) (modification, collaborate)
  Orban et al., Blood 1999*, Sun et al., Blood 1999, Mulhern et al., J Mol Biol 2000, Rossjohn et al., Blood 2000, Carr et al., Cell 2001, Carr et al., Acta crystallographica. Section F, Structural biology and crystallization communications 2006, Kitamura et al., Cell 1991, Woodcock et al., EMBO J 1994, Stomski et al., Mol Cell Biol 1996*, Woodcock et al., J Biol Chem 1996, Klein et al., J Biol Chem 1997*
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IL3-mediated signaling events: IL3/IL3RA/CSF2RB (hexamer) complex (CSF2RB-IL3-IL3RA) → IL3/IL3RA complex (IL3-IL3RA) (modification, collaborate)
  Orban et al., Blood 1999*, Sun et al., Blood 1999, Mulhern et al., J Mol Biol 2000, Rossjohn et al., Blood 2000, Carr et al., Cell 2001, Carr et al., Acta crystallographica. Section F, Structural biology and crystallization communications 2006, Kitamura et al., Cell 1991, Woodcock et al., EMBO J 1994, Stomski et al., Mol Cell Biol 1996*, Woodcock et al., J Biol Chem 1996, Klein et al., J Biol Chem 1997*
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IL3-mediated signaling events: CSF2RB (dimer) complex (CSF2RB) → IL3/IL3RA complex (IL3-IL3RA) (modification, collaborate)
  Orban et al., Blood 1999*, Sun et al., Blood 1999, Mulhern et al., J Mol Biol 2000, Rossjohn et al., Blood 2000, Carr et al., Cell 2001, Carr et al., Acta crystallographica. Section F, Structural biology and crystallization communications 2006, Kitamura et al., Cell 1991, Woodcock et al., EMBO J 1994, Stomski et al., Mol Cell Biol 1996*, Woodcock et al., J Biol Chem 1996, Klein et al., J Biol Chem 1997*
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IL3-mediated signaling events: IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHP2 complex (CSF2RB-JAK2-PTPN11-IL3-IL3RA) → GRB2/GAB2 complex (GRB2-GAB2) (modification, collaborate)
  Edmead et al., Cell Signal 2006, Welham et al., J Biol Chem 1994, Gu et al., J Biol Chem 1997, Craddock et al., J Biol Chem 1997, Gu et al., Mol Cell 1998
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL3-mediated signaling events: IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHP2 complex (CSF2RB-JAK2-PTPN11-IL3-IL3RA) → IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHP2/GRB2/GAB2 complex (CSF2RB-JAK2-PTPN11-IL3-IL3RA-GRB2-GAB2) (modification, collaborate)
  Edmead et al., Cell Signal 2006, Welham et al., J Biol Chem 1994, Gu et al., J Biol Chem 1997, Craddock et al., J Biol Chem 1997, Gu et al., Mol Cell 1998
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL3-mediated signaling events: GRB2/GAB2 complex (GRB2-GAB2) → IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHP2/GRB2/GAB2 complex (CSF2RB-JAK2-PTPN11-IL3-IL3RA-GRB2-GAB2) (modification, collaborate)
  Edmead et al., Cell Signal 2006, Welham et al., J Biol Chem 1994, Gu et al., J Biol Chem 1997, Craddock et al., J Biol Chem 1997, Gu et al., Mol Cell 1998
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL3-mediated signaling events: JAK2 (JAK2) → IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2 complex (CSF2RB-JAK2-IL3-IL3RA) (modification, collaborate)
  Quelle et al., Mol Cell Biol 1994
  Evidence: assay
• NCI Pathway Database IL3-mediated signaling events: JAK2 (JAK2) → IL3/IL3RA/CSF2RB (dodecamer) complex (CSF2RB-IL3-IL3RA) (modification, collaborate)
  Quelle et al., Mol Cell Biol 1994
  Evidence: assay
• NCI Pathway Database IL3-mediated signaling events: IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2 complex (CSF2RB-JAK2-IL3-IL3RA) → IL3/IL3RA/CSF2RB (dodecamer) complex (CSF2RB-IL3-IL3RA) (modification, collaborate)
  Quelle et al., Mol Cell Biol 1994
  Evidence: assay
• NCI Pathway Database IL3-mediated signaling events: IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC complex (CSF2RB-JAK2-SHC1-IL3-IL3RA) → IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC/GRB2/GAB2 complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-IL3-IL3RA) (modification, collaborate)
  Bone et al., Cell Signal 2000, Gu et al., Mol Cell Biol 2000, Edmead et al., Cell Signal 2006, Gu et al., Mol Cell 1998
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL3-mediated signaling events: IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC complex (CSF2RB-JAK2-SHC1-IL3-IL3RA) → GRB2/GAB2 complex (GRB2-GAB2) (modification, collaborate)
  Bone et al., Cell Signal 2000, Gu et al., Mol Cell Biol 2000, Edmead et al., Cell Signal 2006, Gu et al., Mol Cell 1998
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL3-mediated signaling events: IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC/GRB2/GAB2 complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-IL3-IL3RA) → GRB2/GAB2 complex (GRB2-GAB2) (modification, collaborate)
  Bone et al., Cell Signal 2000, Gu et al., Mol Cell Biol 2000, Edmead et al., Cell Signal 2006, Gu et al., Mol Cell 1998
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL3-mediated signaling events: IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2 complex (CSF2RB-JAK2-IL3-IL3RA) → STAT5 (STAT5A/STAT5B) (modification, activates) Azam et al., EMBO J 1995, Chin et al., Blood 1996
  Evidence: assay, physical interaction
• NCI Pathway Database IL3-mediated signaling events: IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2 complex (CSF2RB-JAK2-IL3-IL3RA) → STAT5-active (STAT5A/STAT5B) (modification, activates)
  Azam et al., EMBO J 1995, Chin et al., Blood 1996
  Evidence: assay, physical interaction
• NCI Pathway Database IL3-mediated signaling events: IL3/IL3RA/CSF2RB (hexamer) complex (CSF2RB-IL3-IL3RA) → IL3/IL3RA/CSF2RB (dodecamer) complex (CSF2RB-IL3-IL3RA) (modification, collaborate)
  Orban et al., Blood 1999*, Hansen et al., Cell 2008, Brizzi et al., J Biol Chem 1994, Quelle et al., Mol Cell Biol 1994, Silvennoinen et al., Proc Natl Acad Sci U S A 1993*
  Evidence: assay, physical interaction
• NCI Pathway Database IL3-mediated signaling events: YWHAZ (YWHAZ) → IL3/IL3RA/CSF2RB (dodecamer) complex (CSF2RB-IL3-IL3RA) (modification, collaborate)
  Guthridge et al., Mol Cell 2000, Barry et al., J Biol Chem 2009
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL3-mediated signaling events: YWHAZ (YWHAZ) → IL3/IL3RA/CSF2RB (dodecamer)/YWHAZ complex (CSF2RB-YWHAZ-IL3-IL3RA) (modification, collaborate)
  Guthridge et al., Mol Cell 2000, Barry et al., J Biol Chem 2009
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL3-mediated signaling events: IL3/IL3RA/CSF2RB (dodecamer) complex (CSF2RB-IL3-IL3RA) → IL3/IL3RA/CSF2RB (dodecamer)/YWHAZ complex (CSF2RB-YWHAZ-IL3-IL3RA) (modification, collaborate)
  Guthridge et al., Mol Cell 2000, Barry et al., J Biol Chem 2009
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL3-mediated signaling events: PKA Family-active (PRKACG/PRKACB/PRKACA) → IL3/IL3RA/CSF2RB (dodecamer) complex (CSF2RB-IL3-IL3RA) (modification, activates)
  Guthridge et al., Mol Cell 2000
  Evidence: mutant phenotype, assay
• NCI Pathway Database IL3-mediated signaling events: IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHP2 complex (CSF2RB-JAK2-PTPN11-IL3-IL3RA) → IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2 complex (CSF2RB-JAK2-IL3-IL3RA) (modification, collaborate)
  Welham et al., J Biol Chem 1994, Bone et al., J Biol Chem 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IL3-mediated signaling events: IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHP2 complex (CSF2RB-JAK2-PTPN11-IL3-IL3RA) → SHP2 (PTPN11) (modification, collaborate) Welham et al., J Biol Chem 1994, Bone et al., J Biol Chem 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IL3-mediated signaling events: IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2 complex (CSF2RB-JAK2-IL3-IL3RA) → SHP2 (PTPN11) (modification, collaborate) Welham et al., J Biol Chem 1994, Bone et al., J Biol Chem 1997
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IL3-mediated signaling events: IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC/GRB2/GAB2 complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-IL3-IL3RA) → PI3K complex (PIK3CA-PIK3R1) (modification, collaborate)
  Gu et al., Mol Cell Biol 2000, Gu et al., Mol Cell 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IL3-mediated signaling events: IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC/GRB2/GAB2 complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-IL3-IL3RA) → IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC/GRB2/GAB2/PI3K complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-IL3-IL3RA-PIK3CA-PIK3R1) (modification, collaborate)
  Gu et al., Mol Cell Biol 2000, Gu et al., Mol Cell 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IL3-mediated signaling events: PI3K complex (PIK3CA-PIK3R1) → IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC/GRB2/GAB2/PI3K complex (CSF2RB-JAK2-SHC1-GRB2-GAB2-IL3-IL3RA-PIK3CA-PIK3R1) (modification, collaborate)
  Gu et al., Mol Cell Biol 2000, Gu et al., Mol Cell 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database IL3-mediated signaling events: IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC complex (CSF2RB-JAK2-SHC1-IL3-IL3RA) → IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2 complex (CSF2RB-JAK2-IL3-IL3RA) (modification, collaborate)
  Bone et al., Cell Signal 2000
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL3-mediated signaling events: IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2/SHC complex (CSF2RB-JAK2-SHC1-IL3-IL3RA) → SHC (SHC1) (modification, collaborate) Bone et al., Cell Signal 2000
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL3-mediated signaling events: IL3/IL3RA/CSF2RB (dodecamer)/JAK2/JAK2 complex (CSF2RB-JAK2-IL3-IL3RA) → SHC (SHC1) (modification, collaborate) Bone et al., Cell Signal 2000
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL3-mediated signaling events: IL3/IL3RA/CSF2RB (dodecamer)/YWHAZ/SHC complex (CSF2RB-YWHAZ-SHC1-IL3-IL3RA) → SHC (SHC1) (modification, collaborate) Barry et al., J Biol Chem 2009, Gotoh et al., EMBO J 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL3-mediated signaling events: IL3/IL3RA/CSF2RB (dodecamer)/YWHAZ/SHC complex (CSF2RB-YWHAZ-SHC1-IL3-IL3RA) → IL3/IL3RA/CSF2RB (dodecamer)/YWHAZ complex (CSF2RB-YWHAZ-IL3-IL3RA) (modification, collaborate)
  Barry et al., J Biol Chem 2009, Gotoh et al., EMBO J 1996
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database IL3-mediated signaling events: SHC (SHC1) → IL3/IL3RA/CSF2RB (dodecamer)/YWHAZ complex (CSF2RB-YWHAZ-IL3-IL3RA) (modification, collaborate)
  Barry et al., J Biol Chem 2009, Gotoh et al., EMBO J 1996
  Evidence: mutant phenotype, physical interaction
• Reactome Reaction: CSF2RB → IL3 (reaction) Orban et al., Blood 1999*, Sakamaki et al., EMBO J 1992, Duronio et al., J Biol Chem 1992, Kitamura et al., Cell 1991, Sorensen et al., J Biol Chem 1989, Quelle et al., Mol Cell Biol 1994, Feng et al., Mol Cell Biol 1997, Bone et al., J Biol Chem 1997, Flores-Morales et al., Mol Cell Endocrinol 1998
• Reactome Reaction: CSF2RB → IL3 (indirect_complex) Orban et al., Blood 1999*, Kitamura et al., Cell 1991

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: IL3 — CSF2RB (direct interaction, pull down) Stomski et al., Mol Cell Biol 1996*
• IRef Dip Interaction: IL3 — CSF2RB (physical association, biochemical) Woodcock et al., EMBO J 1994
• IRef Dip Interaction: IL3 — CSF2RB (physical association, experimental interaction detection) Woodcock et al., EMBO J 1994
• IRef Hprd Interaction: Complex of 19 proteins (in vivo) Stomski et al., Mol Cell Biol 1996*
• IRef Hprd Interaction: IL3 — CSF2RB (in vitro) Klein et al., J Biol Chem 1997*
• IRef Hprd Interaction: IL3 — CSF2RB (in vivo) Klein et al., J Biol Chem 1997*
• IRef Intact Interaction: IL3 — CSF2RB (physical association, saturation binding) Hansen et al., Cell 2008
• IRef Ophid Interaction: IL3 — CSF2RB (aggregation, confirmational text mining) Klein et al., J Biol Chem 1997*
• IRef Ophid Interaction: IL3 — CSF2RB (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Brown et al., Blood 1999 : In vitro, we show that an early IL-7R ( + ) lymphoid progenitor population expresses IL-3R and proliferates in response to IL-3 and that IL-3 activates Stat5 comparably to IL-7
Chen et al., Mol Psychiatry 2008 : Since CSF2RB is essential for IL3 signaling, the findings that both IL3 and CSF2RB showed sex-specific and FH-dependent associations suggest that the IL3 pathway is involved in schizophrenia
Algate et al., Blood 1994 : We conclude that IL-3 tightly controls IL-3R expression in the IL-3 dependent FL5.12 cells, whereas steady-state mRNA levels were not altered in the two v-abl transformed derivative cell lines examined in this study
Dan et al., J Immunol 1996 : A subset of type 2, but not type 1, CD4 T cell clones expresses IL-3R and can be stimulated by IL-3 ... Expression of IL-3R on these type 2 T cell clones is induced by TCR stimulation, and subsequent stimulation by IL-3 augmented the proliferation of and IL-4 production by these cells