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HNF4A — PRKAG1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Leclerc et al., Diabetes 2001
(Diabetes Mellitus, Type 1) :
In this study, we show that activation of
AMPK by 5-amino-4-imidazolecarboxamide riboside ( AICAR ) in hepatocytes greatly
diminished HNF-4alpha protein levels and consequently downregulates the expression of HNF-4alpha target genes
Hong et al., J Biol Chem 2003
:
AMPK mediated phosphorylation of
HNF4alpha on serine 304 had a 2-fold effect, reducing the ability of the transcription factor to form homodimers and bind DNA and increasing its degradation rate in vivo
Li et al., J Lipid Res 2010
(Hyperglycemia) :
Glucose increased ATP levels to inhibit
AMPK and
induce HNF4alpha to stimulate CYP7A1 gene transcription