Gene interactions and pathways from curated databases and text-mining

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LRP12 — TNF

Text-mined interactions from Literome

Zang et al., Horm Metab Res 2013 : In contrast, LRP16 overexpression increased TNF-a secretion, suppressed glucose uptake, and attenuated 3T3-L1 cell differentiation
Stein et al., J Natl Cancer Inst 1997 (Colonic Neoplasms) : In this study, we examined the effects of tumor necrosis factor-alpha on MRP and LRP gene expression in the same colon carcinoma cells ... The effects of tumor necrosis factor-alpha on MRP and LRP messenger RNA expression were evaluated by means of reverse transcription and the polymerase chain reaction ; effects on MRP and LRP protein expression were examined by use of specific monoclonal antibodies and flow cytometry ... In transfected cells, the endogenous production of tumor necrosis factor-alpha reduced LRP gene expression ( both messenger RNA and protein ) and increased MRP gene expression ( both messenger RNA and protein ), regardless of cell type