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SERPINE1 — TGFB2

Text-mined interactions from Literome

Ma et al., Placenta 2002 : Regulation of plasminogen activator inhibitor (PAI)-1 expression in a human trophoblast cell line by glucocorticoid ( GC ) and transforming growth factor ( TGF ) -beta
Idell et al., Am J Respir Cell Mol Biol 1992 (Inflammation...) : HPMC PAI-1 is increased by transforming growth factor-beta ( TGF-beta ) and tumor necrosis factor-alpha (TNF-alpha), as is tPA release, while PAI-1 mRNA is unchanged and tPA mRNA is increased
Pandey et al., FASEB J 2005 : Finally, we demonstrate that the PKC pathway is also central for PAI-1 induction in response to insulin and transforming growth factor-beta ( TGF-beta ), two additional molecules which are elevated in obesity and shown to directly induce PAI-1 in the adipocyte
Fleenor et al., Invest Ophthalmol Vis Sci 2006 : This study was undertaken to investigate effects of TGFbeta2 on secretion of fibronectin and the protease inhibitor plasminogen activator inhibitor (PAI)-1 from human TM cell cultures and perfused human ocular anterior segments ... TGFbeta2 also increased secretion of both fibronectin and PAI-1 from TM cells
Slivka et al., Biochim Biophys Acta 1991 : Moreover, when PK-C was down-regulated by PMA pretreatment, subsequent induction of PAI-1 by transforming growth factor beta ( TGF beta ) and tumor necrosis factor alpha (TNF alpha) was unaltered, and induction by lipopolysaccharide (LPS) was decreased by only 50 %
Neumann et al., Invest Ophthalmol Vis Sci 2008 : TGF-beta2 increased the expression of elastin ( 5X [ rtPCR ] /6X [ WB ] ), ColVIalpha2 ( 3X/5X ), ColVIalpha3 ( 7X/9X ), MMP-2 ( 2X/2X ), TIMP-1/-3 ( 1.5X/2X ), and PAI-1 ( 8X/4X ) compared to untreated controls
Zode et al., Glia 2009 (Glaucoma) : BMP-4 dose dependently inhibited TGF-beta2 induced fibronectin ( FN ) and PAI-1 expression in ONH astrocytes and lamina cribrosa ( LC ) cells and also reduced TGF-beta2 stimulation of collagen I, collagen VI, and elastin
Konrad et al., Regul Pept 2009 (Prostatic Neoplasms) : Furthermore, a strong effect of TGF-beta 1 and TGF-beta 2 on the secretion of MMP-9 and PAI-1 was found
Pedroja et al., J Biol Chem 2009 : Plasminogen activator inhibitor-1 regulates integrin alphavbeta3 expression and autocrine transforming growth factor beta signaling ... Fibrosis is characterized by elevated transforming growth factor beta ( TGFbeta ) signaling, resulting in extracellular matrix accumulation and increased PAI-1 ( plasminogen activator inhibitor ) expression
Riccio et al., Nucleic Acids Res 1988 : PAI-1 regulation by glucocorticoids, transforming growth factor-beta ( TGF-beta ) and the phorbol ester PMA is shown to be exerted at the promoter level
Cao et al., Invest Ophthalmol Vis Sci 1995 (Graves Disease) : In this article, the authors examine the effect of transforming growth factor-beta ( TGF-beta ) on PAI-1 expression in orbital fibroblasts
Sawa et al., J Biol Chem 1994 : Secretion of PAI-1 protein assayed by enzyme linked immunosorbent assay declined specifically and dose-dependently in cells exposed to the antisense oligonucleotide treated under basal conditions and after stimulation of PAI-1 expression with transforming growth factor beta ( 0.5 ng/ml for endothelial cell, 5 ng/ml for smooth muscle cell )
Vinogradsky et al., Thromb Res 1997 (Arteriosclerosis...) : T-686 attenuated the augmentation of PAI-1 antigen accumulation induced by transforming growth factor beta in conditioned medium from the human umbilical vein endothelial cells
Samad et al., Mol Med 1997 (Obesity) : PAI-1 gene expression in adipose tissue is also stimulated by transforming growth factor-beta ( TGF-beta )