Gene interactions and pathways from curated databases and text-mining

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CDKN1A — CIB1

Text-mined interactions from Literome

Chang et al., Cancer Lett 1999 (Lung Neoplasms) : Moreover, mimosine induced p21CIP1 expression in H226 and H358 cells, while it activated p27KIP1 expression in H322 cells
Bhatia et al., Nutr Cancer 2001 (Carcinoma, Squamous Cell...) : Quercetin treatment, however, resulted in a moderate increase in Cip1/p21 with no change in Kip1/p27 and a decrease in CDK4 and cyclin D1
Suzuki et al., Hypertens Res 2002 (MAP Kinase Signaling System) : The results also indicated that the constitutive activation of Ras might have induced the persistent expression of p21cip1 and p27kip1, and that this induction of p21cip1 and p27kip1 expression possibly caused the cell cycle arrest at the G1 phase
Gordon et al., Cancer Chemother Pharmacol 2008 (Mesothelioma...) : Bortezomib stabilized or increased protein levels of p21/WAF1 and IAP-1 and to a lesser degree p27/KIP1 , IAP-2, XIAP, and survivin
Liu et al., Mol Carcinog 1998 (Carcinoma, Hepatocellular) : In summary, our results indicated that ( i ) PTDS and DTDS induced apoptosis and G1/S arrest mediated by p53, whereas PDTC, DDTC, and ADTC induced p53 dependent p21 expression leading to G1/S arrest ; ( ii ) PDTC, DDTC, and ADTC induced p21/KIP1/CIP1 expression in a p53 dependent pathway leading to G1/S arrest ; and ( iii ) NFkappaB, AP-1, and bcl-2 were downregulated during PTDS- and DTDS induced apoptosis