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FOXP3 — IL21

Text-mined interactions from Literome

Fantini et al., Eur J Immunol 2007 (Colitis...) : Here we demonstrate that IL-21 , a type-1 cytokine produced by T cells and involved in the pathogenesis of immune mediated diseases, prevents the TGF-beta dependent expression of FoxP3 , the master regulator of T ( reg ) cell commitment, and the induction of suppressive capacity in naive CD4 ( + ) T cells, while promoting the differentiation of Th17 cells
Li et al., Blood 2008 : IL-21 mediated Foxp3 suppression leads to enhanced generation of antigen-specific CD8+ cytotoxic T lymphocytes
Xiao et al., J Immunol 2008 (Autoimmune Diseases) : Herein we show that RA enhances TGF-beta signaling by increasing the expression and phosphorylation of Smad3, and this results in increased Foxp3 expression even in the presence of IL-6 or IL-21
Chaput et al., Gut 2009 (Adenocarcinoma...) : Finally, interleukin 6 and TGF beta 1 synergistically induced the generation of CD8 ( + ) CD25 ( + ) Foxp3 ( + ) T cells ex vivo
Hiramatsu et al., J Leukoc Biol 2010 : Finally, we found that Foxp3 bound to IL-21P and the CNS-2 enhancer and inhibited c-Maf induced IL-21 production modestly but significantly in CD4 ( + ) T cells
Niu et al., Hum Immunol 2010 (Arthritis, Rheumatoid) : IL-21 potently enhances Th17 proliferation and suppresses Foxp3 expression, leading to the expression of RORC