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GRB2 — PLCG2

Pathways - manually collected, often from reviews:

• Reactome Reaction: GRB2 → PLCG2 (reaction) Zhang et al., J Biol Chem 2000, Kim et al., Exp Mol Med 2000, Chong et al., J Biol Chem 2001, Yablonski et al., Mol Cell Biol 2001, Parrini et al., Mol Cell 2002, Wen et al., J Immunol 2002, Nore et al., Biochim Biophys Acta 2003, Tybulewicz et al., Immunol Rev 2003, Wang et al., Traffic 2003, Humphries et al., J Biol Chem 2004, Bos et al., Cell 2007, Peng et al., Science signaling 2010, Ormsby et al., Blood 2011, Todderud et al., Science 1990, Kawakami et al., Mol Cell Biol 1994, Rawlings et al., Science 1996, Park et al., Immunity 1996
• Reactome Reaction: GRB2 → PLCG2 (indirect_complex) Gross et al., J Biol Chem 1999, Brooks et al., J Immunol 2000, Marshall et al., J Exp Med 2000, Zhang et al., J Biol Chem 2000, Fujimoto et al., Immunity 2000, Baba et al., Proc Natl Acad Sci U S A 2001, Yablonski et al., Mol Cell Biol 2001, Rodriguez et al., J Biol Chem 2001, Chiu et al., EMBO J 2002, Wen et al., J Immunol 2002, Xu et al., J Immunol 2002, Coggeshall et al., Proc Natl Acad Sci U S A 1992, Sekiya et al., J Biol Chem 2004, Brooks et al., J Immunol 2004, Roifman et al., Biochem Biophys Res Commun 1992, Kim et al., Mol Cell Biol 2004, Reeve et al., J Immunol 2009, Carter et al., Proc Natl Acad Sci U S A 1991, Peng et al., Science signaling 2010, Weng et al., J Biol Chem 1994, Roifman et al., Biochem Biophys Res Commun 1993, Chalupny et al., EMBO J 1993, Uckun et al., J Biol Chem 1993, de Weers et al., J Biol Chem 1994, Saxton et al., J Immunol 1994, Smit et al., J Biol Chem 1996, Bubeck Wardenburg et al., J Biol Chem 1996, Kuwahara et al., Int Immunol 1996, Hendricks-Taylor et al., J Biol Chem 1997, Harmer et al., Mol Cell Biol 1997, Fu et al., J Biol Chem 1997, Bae et al., J Biol Chem 1998, Fu et al., Immunity 1998

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• MIPS CORUM PLC-gamma-2-SLP-76-Lyn-Grb2 complex: PLC-gamma-2-SLP-76-Lyn-Grb2 complex complex (GRB2-LCP2-LYN-PLCG2) Gross et al., Eur J Biochem 1999
• IRef Corum Interaction: Complex of GRB2-PLCG2-LYN-LCP2 (association, pull down) Gross et al., Eur J Biochem 1999
• IRef Hprd Interaction: Complex of 50 proteins (in vivo) Gross et al., Eur J Biochem 1999
• IRef Hprd Interaction: Complex of 26 proteins (in vivo) Janssen et al., Nat Immunol 2003*
• IRef Intact Interaction: Complex of MAP2K4-BLNK-CD2AP-DOK3-GRB2-PLCG2 (association, anti bait coimmunoprecipitation) Oellerich et al., EMBO J 2011
• IRef Intact Interaction: PLCG2 — GRB2 (physical association, peptide array) Wu et al., Proteomics 2007

Text-mined interactions from Literome

MacDonald et al., J Biol Chem 2000 : Grb2 binding to TrkA is independent of Shc, FRS-2, phospholipase Cgamma-1 , rAPS, and SH2B and is observed in in vitro binding assays, yeast two-hybrid assays, and in co-immunoprecipitation assays
Peruzzi et al., J Immunol 2007 (Calcium Signaling) : We found that CIN85 overexpression inhibits the FcepsilonRI induced tyrosine phosphorylation of phospholipase Cgamma , thus altering calcium mobilization
Blume-Jensen et al., J Biol Chem 1994 : The ligand activated Kit/SCF-R associated weakly with GRB2 and induced only little tyrosine phosphorylation of phospholipase C-gamma in porcine aortic endothelial cells transfected with Kit/SCF-R