Channavajhala et al., J Biol Chem 2003
(MAP Kinase Signaling System) :
In addition, we demonstrate that hKSR-2 co-immunoprecipitates with Cot and that co-expression of hKSR-2 with Cot significantly reduces Cot mediated MAPK and NF-kappaB activation
RodrÃguez et al., Cell Signal 2008
:
In addition, the increase in COX2 expression and the activation of Erk1/2 regulated by Cot are essential for the induction of cell migration
Sanz-Garcia et al., J Biol Chem 2013
(Drug-Induced Liver Injury...) :
Cot/tpl2 ( MAP3K8 ) activates MKK1/2-Erk1/2 following stimulation of the Toll-like/IL-1 receptor superfamily