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CASP8 — SLPI
Text-mined interactions from Literome
Lahusen et al., Mol Carcinog 2003
:
Alp caused early activation of both
caspase-8 and -9, leading to cleavage of caspase-3 and poly ( ADP-ribose ) polymerase ( PARP ) ... Studies of mitochondrial membrane potential also demonstrated that Alp is able to disrupt mitochondrial potential in the presence of ZVAD, suggesting that the
activation of
caspase-9 by
Alp follows mitochondrial perturbation ... In summary, these experiments suggest that
Alp activates
caspase-9 via mitochondrial perturbation
Mogi et al., J Biol Chem 2003
:
Peptide inhibition of
caspase activity
led to a dramatic reduction in
ALP activation and PTH induced production of cAMP in BMP-4 treated cells