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HSPB1 — PDGFB

Text-mined interactions from Literome

Tangkijvanich et al., J Cell Physiol 2002 : PDGF-BB also induced activation of p38 MAP kinase, its downstream effector, heat shock protein (HSP) 27 , ERK 1 and ERK 2, and p125 focal adhesion kinase (FAK) ... Selective antagonism of p38 MAP kinase blocked PDGF-BB stimulated HSP 27 phosphorylation, membrane ruffling, and migration, but did not alter PDGF-BB induced proliferation
Takenaka et al., J Cell Biochem 2004 : SB203580, a specific inhibitor of p38 MAP kinase, reduced the PDGF-BB stimulated phosphorylation of HSP27 at both Ser-15 and -85, and phosphorylation of p38 MAP kinase
Lee et al., Cardiovasc Res 2007 (MAP Kinase Signaling System) : PDGF-BB increased the phosphorylation of extracellular signal regulated kinase ( ERK ) 1/2, p38 MAPK, and HSP27 , which were significantly inhibited by piceatannol and in Syk-knockdown cells ... SB203580, but not PD98059, inhibited the phosphorylation of HSP27 induced by PDGF-BB in RASMC
Chen et al., Mol Cell Biochem 2009 : The phosphorylation of HSP27 was induced by AngII and PDGF-BB in a time- and concentration dependent manner in VSMCs, which was significantly blocked by the HSP inhibitor Quercetin in a concentration dependent manner
Chen et al., Mol Cell Biochem 2010 : Within a given concentration, the phosphorylation of HSP27 induced by AngII and PDGF-BB was blocked by the specific P38MAPK inhibitor SB202190, the specific PI3K inhibitor LY294002 and the specific ERK1/2 inhibitor U0126 in a concentration dependent manner, with a peak inhibition rate at 87.2 %, 78.4 % and 37.3 %, respectively, induced by AngII ( P < 0.01 ), with a peak inhibition rate at 85.0 %, 55.3 % and 41.0 %, respectively, induced by PDGF-BB ( P < 0.01 ) .The migration of VSMCs induced by AngII and PDGF-BB was inhibited by 100 micromol/l SB202190, 30 micromol/l LY294002, and 30 micromol/l U0126, with a inhibition rate at 60.1 %, 71.7 % and 47.3 %, respectively, provoked by AngII ( P < 0.01 ), with a inhibition rate at 55.3 %, 55.6 % and 38.1 %, respectively, provoked by PDGF-BB ( P < 0.01 )
Kato et al., Thromb Res 2010 : These results strongly suggest that the collagen induced phosphorylation of HSP27 via p44/p42 MAPK is sufficient for releases of 5-HT, PDGF-AB and sCD40L from human platelets
Phalitakul et al., Biochem Biophys Res Commun 2012 : Vaspin significantly inhibited PDGF-BB induced phosphorylation of p38 and heat shock protein (HSP) 27 as well as ROS generation ... NAC significantly inhibited the PDGF-BB induced phosphorylation of p38 and HSP27