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REN — TNF
Text-mined interactions from Literome
Wang et al., J Cell Physiol 2000
:
These data indicate that the induction of AEC apoptosis by
TNF-alpha requires a functional
renin/angiotensin system (RAS) in the target cell
Todorov et al., Am J Physiol Regul Integr Comp Physiol 2002
:
Tumor necrosis factor-alpha inhibits
renin gene expression ... Therefore we have tested the
effect of
TNF-alpha on
renin transcription in As4.1 cells, which represent transformed mouse JG cells, and in native mouse JG cells in culture ...
TNF-alpha inhibited
renin gene expression via an inhibition of the transcriptional activity, targeting the proximal 4.1 kb of the renin promoter in As4.1 cells ...
TNF-alpha also
attenuated forskolin stimulated
renin gene expression in primary cultures of mouse JG cells ... Our data suggest that
TNF-alpha inhibits
renin gene transcription at the cellular level and thus may act as a modulator of renin synthesis in ( physio ) pathological situations
Todorov et al., J Biol Chem 2004
:
Tumor necrosis factor-alpha activates NFkappaB to
inhibit renin transcription by targeting cAMP-responsive element ... Our results strongly suggest that NFkappaB mediates the
effect of
TNFalpha on
renin transcription targeting a CRE in the mouse renin promoter
Fowler et al., Am J Physiol Endocrinol Metab 2009
(Obesity) :
In contrast, forskolin and
TNFalpha each
increased renin protein secretion 12- and sevenfold, respectively
Ino et al., Arterioscler Thromb Vasc Biol 2009
(Disease Models, Animal) :
Interestingly,
TNF-alpha induced
renin activity and angiotensin II production in HUVECs were also blunted by aliskiren
Antonipillai et al., Endocrinology 1990
:
Tumor necrosis factor and interleukin-1 may
regulate renin secretion ... We have studied the direct
effects of recombinant and purified
TNF and IL-1 on
renin secretion using both static incubations and perifusions of rat renal cortical slices ...
TNF similarly
induced renin release [ control, 97 +/- 6 % ; TNF ( 10 U/ml ), 151 +/- 13 % ; P less than 0.005 ] ...
TNF and recombinant human IL-1 beta ( rhIL-i beta ) also
blocked the inhibitory actions of angiotensin-II ( AII ) on
renin release [ control, 100 +/- 3 % ; AII ( 2 X 10 ( -7 ) M ), 80 +/- 5 % ; AII plus TNF ( 20 U/ml ), 102 +/- 7 % ; AII plus rhIL beta ( 10 U/ml ), 106 +/- 6 % ; both P less than 0.02 vs. AII ] ... The stimulatory
effects of
TNF and IL-1 on
renin were reversible ... These results suggest that IL-1 and
TNF are renin secretagogues and can also
block the inhibitory actions of AII on
renin ... Since the
effect of
TNF and IL-1 on
renin can be blocked by a ( CO ) inhibitor, the studies indicate a role of prostaglandins in their action
Hermus et al., J Steroid Biochem Mol Biol 1990
:
IL1 and
TNF inhibit aldosterone production by rat adrenocortical cells in vitro and
stimulate renin release by rat renal cortical cells
Jikihara et al., J Clin Endocrinol Metab 1995
:
Tumor necrosis factor-alpha and interleukin-1 beta
inhibit the synthesis and release of
renin from human decidual cells
Jikihara et al., Biol Reprod 1996
:
In addition to inhibiting basal renin expression, IFN gamma potentiated the inhibitory
effect of
tumor necrosis factor alpha (TNF alpha) on
renin expression