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IL6 — MTX1

Text-mined interactions from Literome

Neuman et al., Clin Biochem 1999 : MTX + EtOH increased the release of IL 6 , IL 8 and TNF alpha by 1.0, 1.2, and 1.1 times, respectively
Sung et al., Immunopharmacology 2000 (Arthritis, Rheumatoid) : In the present study, we investigated the effects of MTX on the gene expression and synthesis of interleukin-6 (IL-6) , and the proliferative activity and the production of ROS in the fibroblast-like synoviocytes ( FLSs ) obtained from the patient of RA
Seitz et al., Rheumatology (Oxford) 2000 (Arthritis, Rheumatoid) : Moreover, PBMNC of healthy donors revealed that MTX also stimulated TIMP-1 and IL-6 release in vitro, IL-6 being partially responsible for the induction of TIMP-1 production
Yoshida et al., J Rheumatol 2005 : We investigated the effect of MTX on IL-6 synthesis induced by these agents in MC3T3-E1 cells ... MTX significantly suppressed IL-6 synthesis stimulated by these agonists in a dose dependent manner, although MTX alone had no effect on the levels of IL-6 ... In addition, MTX significantly inhibited the enhancement by IL-17 of TNF-alpha stimulated IL-6 synthesis ... MTX reduced the levels of IL-6 induced by 12-O-tetradecanoylphorbol 13-acetate, a direct activator of protein kinase C ( PKC ), suggesting that MTX inhibits PKC signals for IL-6 synthesis ... MTX suppresses IL-6 synthesis stimulated by various inflammatory agonists in osteoblasts
Hobl et al., Clin Exp Rheumatol 2011 (Arthritis, Rheumatoid) : MTX reduces the production of pro-inflammatory cytokines such as interleukin (IL)-1, IL-2, IL-6 and interferon (INF)-?, while the gene expression of anti-inflammatory Th2 cytokines like IL-4 and IL-10 is increased - altogether resulting in the anti-inflammatory effect
Yi et al., The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2012 : Also, the number of IL-6R ( + ) cells was increased by MTX in the 3 cell lines mentioned and increased by 5-FU in the H460 cell line
Crilly et al., J Rheumatol 1995 (Arthritis, Rheumatoid) : To investigate the effect of oral methotrexate (MTX) on circulating levels of interleukin 6 (IL-6) and soluble IL-2 receptor ( sIL-2R ) in patients with rheumatoid arthritis ( RA ) ... MTX significantly reduced IL-6 and sIL-2R after 12 weeks of therapy, and although the levels remained low at 24 weeks of therapy, the reduction was not significant
Meyer et al., J Rheumatol 1993 (Arthritis, Rheumatoid) : MTX had no effect on interleukin 1 stimulated production of prostaglandin E, hyaluronic acid and collagenase