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BPNT1 — FGF2
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Chung et al., J Neurochem 2000
:
The immediate early gene
pip92 has been identified in serum stimulated BALB/c 3T3 fibroblasts, activated T lymphocytes treated with cycloheximide, and
fibroblast growth factor stimulated hippocampal cells during neuronal differentiation
Park et al., J Neurochem 2007
:
The immediate early gene
pip92 is rapidly and transiently
induced by serum,
basic fibroblast growth factor (bFGF) , nerve growth factor (NGF) and phobol ester, as well as various toxic stimuli ... Significant and robust activation of c-Jun N-terminal Kinase (JNK), Rac1 and extracellular signal regulated kinase ( ERK ) appeared to be important for
pip92 induction in
response to
bFGF ... Stimulation of Pak1 dependent Elk1 was required for the
bFGF induced activation of
pip92
Chung et al., Mol Cell Biol 1998
:
To determine the mechanism by which this occurs and to identify novel Raf activated signaling pathways, we investigated the
induction of the
pip92 promoter by both
FGF and an estradiol activated Raf-1-estrogen receptor fusion protein ( deltaRaf-1 : ER ) in H19-7 cells